Recombinant Human Proton-coupled zinc antiporter SLC30A8 (SLC30A8)

1. ZnT8 Arg325Trp polymorphism is associated with enhanced inflammation in type 2 diabetes. PMID: 30142362
2. the effects of the interaction between ZNT8 rs13266634 and dietary factors on the risk of Metabolic syndrome S were investigated in this study. PMID: 28490771
3. HLA-A*24, the SLC30A8 T allele and high BMI are associated with poor graft outcome in type 1 diabetics undergoing pancreatic islet transplantation. PMID: 29679103
4. The findings reported herein that the diabetes risk genotype C/C at SNP rs13266634 of the SLC30A8 gene encoding the beta-cell Zn transporter ZnT8 is associated with a higher total islet Zn concentration, is potentially of clinical significance. PMID: 28352089
5. Results demonstrate that SLC30A8 rs2466293 was associated with T1D predisposition in brazilians with non-European descents. PMID: 28303020
6. is a valuable biological marker to classify newly-diagnosed diabetics PMID: 29288641
7. common single nucleotide polymorphisms confer risk susceptibility to type 2 diabetes; DNA methylation levels are increased in type 2 diabetes patients [review] PMID: 26593983
8. These findings of differential cytolocation of ZnT8 isoforms could be relevant for beta-cell zinc metabolism in health and disease. PMID: 28965566
9. rs13266634/T SNP (SLC30A8) is a suggestive protective variant against gestational diabetes mellitus development. PMID: 28072873
10. High Arg-325 variant in ZnT8 is associated with Risk for Type-2 Diabetes. PMID: 27875315
11. The results provide a strong evidence for independent association between type 2 diabetes mellitus and SNPs for in TCF7L2 and SLC30A8. PMID: 27310578
12. this is the first study to report a significant association between the R325W C-allele of SLC30A8 and increased risk of developing gestational diabetes mellitus. All of the autoantibody positive women with GDM who developed postpartum type 1 diabetes were positive for autoantibodies against glutamic acid decarboxylase. Thus ZnT8A did not have any additional predictive value in postpartum development of type 1 diabetes. PMID: 27003436
13. Although previous meta-analyses have shown that this association was only found in Asian and European groups, and not in African populations, our analysis revealed the deleterious effect of SLC30A8 rs13266634 on type 2 diabetes mellitus in an African population when stratified by ethnicity under additive model even with a small number of studies. PMID: 26832344
14. Results indicate a lack of association of the SLC30A8 SNPs with type 2 diabetes in Mexican American families. PMID: 27896278
15. The hZnT8 R325W transgenic line had lower pancreatic [Zn(2+)]i and proinsulin and higher insulin and glucose tolerance compared with control littermates after 10 weeks of a high-fat diet in male mice. The converse was true for the hZnT8 WT transgenic line, and dietary Zn(2+) supplementation also induced glucose intolerance. PMID: 27899481
16. Data indicate that gestational weight gain may modify SLC30A8 variant on long-term glycemic changes, highlighting the importance of gestational weight control in the prevention of postpartum hyperglycemia in women with GDM. PMID: 27600066
17. We investigated the association of the polymorphisms rs13266634 (SLC30A8) in a case-control study in Euro-Brazilians with gestational diabetes. The minor allele frequencies, for healthy and gestational diabetes, respectively, for the T-allele (SLC30A8 gene rs13266634) were 27.8% (95%CI = 23-32%) vs 23.5% (95%CI = 18-29%), P = 0.227. Genotype comparisons showed no significant difference. PMID: 28363002
18. Two miR-binding SNPs SLC30A8 rs2466293 and INSR rs1366600 increased Gestational diabetes mellitus susceptibility. Functional studies were required to confirm the underlying mechanism. PMID: 28190110
19. we have successfully constructed a T1D phage display antibody library and identified two ZnT8-specific scFv clones, C27 and C22. These ZnT8-specific scFvs are potential agents in immunodiagnostic and immunotherapy of T1D PMID: 27270580
20. Results obtained for ZnT8A measurement using ELISA were consistent with previous data. Such investigation could improve the risk stratification and would be integrated in our daily practice PMID: 27363941
21. Detection of ZnT8 antibodies in blood precedes detection of classical islet antibodies in children at risk of developing diabetes mellitus type 1. PMID: 26824044
22. Studies indicate that people who have particular mutations in a gene called SLC30A8 (Solute carrier family 30, member 8) are 65% less likely to get diabetes. PMID: 26957571
23. Association between SLC30A8 rs13266634 Polymorphism and Type 2 Diabetes Risk PMID: 26214053
24. Size and the direction of the effect of SLC30A8 risk alleles in man. PMID: 25287711
25. Zinc supplementation appears to affect the early insulin response to glucose differentially by rs13266634 genotype and could be beneficial for diabetes prevention and/or treatment for some individuals based on SLC30A8 variation. PMID: 25348609
26. Suggest rs3019885 SLC30A8 SNP is not a susceptibility factor for abdominal aortic aneurysms in an Italian population. PMID: 24423473
27. These data demonstrate that T1D patients may have single amino acid-specific autoantibodies directed against either ZnT8R or ZnT8W and that the autoantibody affinity to the respective variant may be different. PMID: 25178386
28. zinc transporter 8 and MAP3865c homologous epitopes are recognized by Hashimoto's thyroiditis subjects from Sardinia PMID: 24830306
29. Thus, rs13266634 polymorphism might play a significant role in lipid metabolism and cardiovascular risk in HIV/hepatitis C-coinfected patients. PMID: 24499956
30. No significant difference was found between the normal and diabetic subjects regarding the rs13266634 C/T polymorphism in SLC30A8 gene. PMID: 24449369
31. Individual common and an aggregate of rare genetic variation in SLC30A8 are associated with measures of beta-cell function in the diabetes prevention program. PMID: 24471563
32. Our study suggested that the C allele of rs13266634 was associated with higher odds of T2D, and higher plasma zinc was associated with lower odds. The inverse association of plasma zinc concentrations with T2D was modified by SLC30A8 rs13266634. PMID: 24306209
33. Antibodies for ZnT8 is related to age and metabolic status at diagnosis as well as HLA genotype but does not significantly improve the detection rate of beta-cell autoimmunity in Finnish children and adolescents affected by Type 1 diabetes. PMID: 23861236
34. SLC30A8 haploinsufficiency protects against type 2 diabetes, suggesting ZnT8 inhibition as a therapeutic strategy in type 2 diabetes prevention. PMID: 24584071
35. Men with two copies of the allele that protects against type 2 diabetes showed less post-exercise bout strength loss, less soreness, and lower creatine kinase values. PMID: 24101675
36. Zinc transporter 8 and MAP3865c homologous epitopes are recognized at T1D onset in Sardinian children. PMID: 23696819
37. ZnT8A were more common and more persistent in patients with LADA compared to adult-onset type 1 diabetes, but their presence was not associated with specific phenotypic characteristics. PMID: 23194113
38. SLC30A8 regulates hepatic insulin clearance. PMID: 24051378
39. Analysis of ZnT8A increased the diagnostic sensitivity of islet autoantibodies for T1D as only 7% remained islet autoantibody negative. The association between DQ6.4 and all three ZnT8A may be related to ZnT8 antigen presentation by the DQ6.4 heterodimer. PMID: 22957668
40. Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A*24 alleles at the onset of type 1 diabetes. PMID: 23396399
41. ZnT8-specific CD4(+) T cells are skewed towards Th1 cells in type 1 diabetes mellitus patients. PMID: 23390544
42. Carriers of the TT genotype of the SLC30A8 gene predict lower stimulated C-peptide levels 12 months after type 1 diabetes diagnosis. PMID: 22686132
43. The humoral autoreactivity to ZnT8 depends on the clinical phenotype, which may provide clues to understand the role of this protein in the pathogenesis of type 1 diabetes. PMID: 22447136
44. The SLC30A8 gene variation does not appear to contribute a genetic basis for the co-occurrence of schizophrenia and T2DM PMID: 22778022
45. At diagnosis of type 1 diabetes in non-Swedes, the presence of ZnT8-RA autoantibodies rather than ZnT8-WA was likely due to effects of HLA-DQ2 and the SLC30A8 genotypes. PMID: 22787139
46. Data conclude that type 2 diabetes is associated with the AA genotype of rs11558471 in the human SLC30A8 gene. PMID: 22653633
47. ZNT8 expression responds to variation in zinc and lipid levels in human beta cells, with repercussions on insulin secretion. PMID: 22582094
48. ZnT8A testing in combination with other autoantibodies facilitates disease prediction, despite the biomarker not being under the same genetic control as the disease. PMID: 22526605
49. ZnT8-reactive CD8(+) T cells are directed against the ZnT8(186-194) epitope and are detected in a majority of IDDM patients. The exceptional immunodominance of ZnT8(186-194) may point to common environmental triggers precipitating beta cell autoimmunity. PMID: 22526607
50. ZnT8A identified a subset at higher diabetes risk. ZnT8A predicted diabetes independently of ICA, the standard BAA, age, and HLA type. ZnT8A should be included in type 1 diabetes prediction and prevention studies PMID: 22446173

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HGNC: 20303

OMIM: 125853

KEGG: hsa:169026

STRING: 9606.ENSP00000415011

UniGene: Hs.532270