SLC30A8

SLC30A8 encodes the zinc transporter 8 (ZnT8) protein. This protein, also known as CDA1, is predominantly expressed in pancreatic beta - cells. Its main role is to transport zinc ions into insulin granules, which is crucial for insulin crystallization and storage. ZnT8 is involved in the insulin secretion pathway, directly impacting glucose homeostasis.
Abnormal function of ZnT8 is associated with type 2 diabetes, and specific gene variants can increase disease susceptibility. In drug development, ZnT8 has emerged as a potential therapeutic target. Some ongoing research aims to modulate its activity to improve insulin secretion and manage diabetes more effectively.