Recombinant Mouse G protein-activated inward rectifier potassium channel 2 (Kcnj6)

1. GIRK2 isoform balance within a neuron can impact the processing of afferent inhibitory input and associated behavior. PMID: 28487514
2. Locomotor activity of the mice was not changed compared to that of GIRK2(floxed) mice, when tested in the open field PMID: 29180115
3. Results indicate that the properties and inhibitory activity of dorsal raphe neurons are highly regulated by G protein-coupled inwardly rectifying K+ (GIRK) 2 subunit-containing channels, introducing GIRK channels as potential candidates for studying the pathophysiology and treatment of affective disorders. PMID: 28196855
4. Increased Kcnj6 gene dose is necessary for synaptic and cognitive dysfunction in the animal model of Down Syndrome. PMID: 28342823
5. The GABABR-coupled GIRK2 channel is necessary for the GABABR agonist-induced infantile spasms phenotype in the Ts mouse and may represent a novel therapeutic target for the treatment of infantile spasms in Down syndrome. PMID: 27462820
6. It was concluded that GIRK2, through its dual responsiveness to G protein beta-gamma and Na+, mediates a form of neuronal inhibition that is amplifiable in the setting of excess electrical activity. PMID: 27074662
7. cholesterol did not affect the unitary conductance of GIRK2, it significantly enhanced the frequency of channel openings. PMID: 28213520
8. Results indicate that GIRK channels formed by GIRK2 subunits determine depression-related behaviors as well as basal and 5-HT1A receptor-mediated dorsal raphe neuronal activity PMID: 25956878
9. This study showed that spontaneous GIRK2 mutations causing cerebellar pathology are impaired in motor functions during the neonatal period. PMID: 25907855
10. This study demonstrated that the residue Ser-196 in Kir3.2 is involved in conferring PKC-mediated inhibition to the channel. PMID: 26490875
11. In the ventral tegmental area, GABA neurons express both GIRK2 (and GIRK1) subunits. PMID: 25948263
12. Gbeta-gamma and PIP2 must be present simultaneously to activate GIRK2. PMID: 25049222
13. Ligand-operated activation of Kir3.2 appears to cause dilation of the pore at the cytoplasmic domain, and is regulated conformationally. PMID: 24244570
14. A subcellular GIRK2c/GIRK3 pathway is identified that regulates excitability of ventral tegmental area dopamine neurons. PMID: 24811384
15. The results of this study show that Girk2 gene mutation alters electric activity of LC neurons in vivo. PMID: 23040084
16. Altogether, these findings shed new light on the developmental regulation of GIRK channels in the cerebellum PMID: 23261870
17. In the dorsal horn of the developing rat, K(ir)3.1 and K(ir)3.2 were expressed at mature levels from birth. PMID: 23219908
18. GIRK2 mediates the mGluR-sensitive current in unipolar brush cells PMID: 22528965
19. GIRK2 is expressed in nearly every human pigmented neuron or mouse immunoreactive tyrosine hydroxylase-immunoreactive neuron in both the substantia nigra and ventral tegmental areas. PMID: 22252428
20. biophysical analysis of conductance properties of the inwardly rectifying channel, Kir3.2 PMID: 23022491
21. GIRK modulation occurs by channel assembly with R7-RGS/Gbeta5 complexes under allosteric control of R7 RGS-binding protein (R7BP). PMID: 23169654
22. This study demonistrated that kcnj6 gene expression in mouse dorsal raphe nucleus PMID: 22534482
23. Data describe the developmental regulation and subcellular diversity of neuronal GIRK/Kir3 channels, and support the contention that distinct subpopulations of GIRK channels exert separable influences on neuronal excitability. PMID: 22098295
24. studies in two different mammalian species point to a conserved mechanism by which the GIRK2 inward-rectifying K(+) ion channels support sperm function during fertilization PMID: 22054410
25. The mechanisms of regulation of GIRK by Galpha(i/o) using wild-type Galpha(i3) (Galpha(i3)WT) and Galpha(i3), were investigated. PMID: 21795707
26. Altered neurotransmission in the limbic system of Girk2 knock-out mice involves secondary adaptations facilitating glutamatergic signaling. PMID: 20557431
27. GIRK2 knockout mice demonstrate a transient hyperactive phenotype with initially high motor activity and slower habituation, increased levels of spontaneous locomotion during dark phase in their home cages, and impaired habituation in the open-field test. PMID: 11823889
28. activation involved in mechanisms of analgesia PMID: 12493843
29. contributes to channel-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences PMID: 12496346
30. results do not support the notion that Kir3.2 potassium channel mediates the capacity of inhaled anesthetics to produce immobility PMID: 12707131
31. wvGIRK2 channels in native dopamine neurons are not permeable to Ca2+ and when activated by D@ and GABAB receptors mediate depolarization through VGCC channels PMID: 15240766
32. Kir3.2-containing K+ channels on dendritic spines preferentially mediate the effect of GABA. PMID: 16624949
33. Ts65Dn mice wirh Girk2 mutations display significantly increased hypothermic responses to 8-OH-DPAT, a serotonin receptor agonist. PMID: 16708025
34. GIRK2 overexpression may adversely affect cerebellar circuitry in down syndrome animal model's vestibulocerebellum and dorsal cochlear nucleus. PMID: 16783527
35. These results indicate that increased expression of GIRK2 containing channels have functional consequences that likely affect the balance between excitatory and inhibitory neuronal transmission. PMID: 17093127
36. GIRK2 exhibited the most widespread and robust labeling in the cerebellum, with labeling particularly prominent in granule cells and Purkinje neurons , glogi cells,unipolar brush cells. PMID: 18088366
37. Inhibition of adrenergic tone is required for the induction of dependence, and channels containing GIRK2 and GIRK3 serve as inhibitory gate. PMID: 18400906
38. Results describe opioid-induced postsynaptic inhibition in locus coeruleus neurons from wild-type and GIRK2/GIRK3(-/-) mice at baseline and following chronic morphine treatment. PMID: 18702733
39. Comparison of high-resolution structures of inwardly rectifying K(+) channels suggests a model for activation of GIRK channels using this hydrophobic alcohol-binding pocket. PMID: 19561601

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KEGG: mmu:16522

STRING: 10090.ENSMUSP00000097108

UniGene: Mm.328720