Recombinant Mouse Interleukin-1 receptor-like 1 (Il1rl1)

1. Taken together, our data provide the evidence that ST2 deficiency in early phase of sepsis downregulates myeloid precursors, inflammatory NK and dendritic cells PMID: 30001716
2. Studied the association of interleukin 1 receptor-like 1 deficiency (St2) on renal ischaemia-reperfusion injury in euglycaemic and hyperglycaemic mice. PMID: 28916390
3. sST2 is downregulated in high-metastatic cells compared with low-metastatic human and mouse CRC cells. Knockdown of sST2 in low-metastatic cells enhances tumour growth, metastasis and tumour angiogenesis, whereas its overexpression in high-metastatic cells suppresses these processes. PMID: 27882929
4. IL-33/ST2 can induce production of proinflammatory cytokines, such as TNF-alpha and IL-6, through production of IL-13 in Plasmodium chabaudi-infected BALB/c mice, suggesting that IL-33/ST2 play a critical role in inflammatory responses to malaria infection. PMID: 28359899
5. these results provide new insights into the mechanisms by which intestinal epithelial cells , via IL-33/ST2 axis, may control pro-inflammatory TH17 cells in the small intestine to sustain homeostasis PMID: 28198366
6. Results indicate that IL-33/ST2 signaling is functionally present in primary sensory neurons and contributes to pruritus in poison ivy ACD. Blocking IL-33/ST2 signaling may represent a therapeutic approach to ameliorate itch and skin inflammation related to poison ivy allergic contact dermatitis. PMID: 27821781
7. CLOCK temporally gates mast cell responses to IL-33 via regulation of ST2 expression. Our findings provide novel insights into IL-33/mast cell-associated physiology and pathologies. PMID: 28259547
8. an increased prevalence in neonatal mortality was observed in litters from dams lacking ST2 PMID: 29133293
9. Taken together, the data demonstrate a critical role of MyD88 in DCs and of IL-33 signaling via ST2 in MC903-induced Atopic dermatitis (AD). These data suggest that IL-33/IL-33R may be a therapeutic target of AD. PMID: 28383552
10. Heligmosomoides polygyrus Alarmin Release Inhibitor (HpARI) prevents binding of active interleukin-33 (IL-33) to the IL-33 receptor. PMID: 29045903
11. mice deficient in the receptor for IL-33 (Il1rl1-/-) demonstrated enhanced lung clearance of Aspergillus fumigatus PMID: 28784844
12. This stuidy shown that the mRNA expression of IL-33 and ST2 receptors is increased in the CNS of Rocio virus-infected WT mice and that ST2(-/-) mice showed increased susceptibility to infection. PMID: 27334012
13. Liver Treg cells show a high expression of ST2, a cellular receptor for tissue alarmin IL-33, which is strongly upregulated in the liver of infected mice. These results illustrate the importance of IL-33 in the suppressive function of liver Treg cells during Cytomegaloviruses (CMVs) infection. PMID: 28448566
14. These results shed light on endogenous IL-33/ST2 signaling as a potential immune regulatory mechanism that serves to promote beneficial microglial responses and mitigate ischemic brain injury after stroke. PMID: 28389473
15. Plasmodium berghei infection triggered a dramatic increase of IL-33 expression by oligodendrocytes, through ST2 pathway. PMID: 28448579
16. Data, including data from studies using knockout mice, suggest that signal transduction via IL33/ST2L (interleukin 33/interleukin-33 receptor) plays a cardioprotective role in myocardial remodeling under mechanical stress (which leads to left ventricular hypertrophy and heart failure). PMID: 28450225
17. IL-33 acts as a potent immune modulator protecting the liver through activation of ST2(+) Treg cells and control of natural killer cells in immune cell-mediated hepatitis. PMID: 27340126
18. IL-33/ST2 pathway plays a role in enhancing inflammation and tissue damage at the site of acute inflammation. PMID: 27222019
19. this study shows that the functional IL-33R is expressed on eosinophil progenitors, basophil progenitors and mast cell progenitors PMID: 27568595
20. the present study hypothesized that IL-33, as a 'master switch' of tissue repair that is secreted from dying or apoptotic cells, activated the IL-33-ST2-MyD88-TRAF6 pathway, amplified Th2-type responses and was involved in the pulmonary fibrosis process, via its receptor ST2, a stable marker of Th2 cells. PMID: 27358001
21. ST2 deletion increases inflammatory bone loss in experimental periapical lesions in mice. PMID: 25595464
22. ST2 receptor invalidation maintains wound inflammation, delays healing and increases fibrosis PMID: 26314835
23. the results of the present study suggest a possible asthma phenotype that involves the IL-33/ST2 pathway and is important for the development of airway inflammation and AHR in the peripheral airways. PMID: 26609909
24. Data suggest that IL-33 and ST2 function as a developmental switch to license thermogenesis during the perinatal period. PMID: 27453471
25. The IL-33/ST2 axis may play a crucial role in the pathogenesis of angiostrongylosis. PMID: 24657070
26. Blockade of ST2 markedly improves survival of lymphocytic choriomeningitis virus -infected Prf1-/- mice and reduces the severity of multiple disease parameters, including serum levels of IFNgamma. PMID: 26518437
27. the IL-33/ST2 axis specifically controls visceral adipose tissue-Treg cell development was revealed. PMID: 26277897
28. The activity of IL-33 at its receptor ST2 is terminated by the formation of two disulphide bridges, resulting in conformational change that disrupts the ST2 binding site. PMID: 26365875
29. IL-33/ST2 may involve the regulation of ocular immunopathology induced by Toxoplasma gondii infection. PMID: 25693767
30. ST2/IL-33 signaling contributes to neuropathic pain by activation of astroglial JAK2-STAT3 cascade and neuronal CaMKII-CREB cascade. PMID: 26352378
31. IL-33 receptor ST2 amplifies the expansion of NK cells and enhances host defense during mouse cytomegalovirus infection. PMID: 25926677
32. The IL-33/ST2 axis augments effector T-cell responses during acute GVHD. PMID: 25814531
33. role of the IL-33/ST2 pathway in Plasmodium berghei experimental cerebral malaria development PMID: 25682948
34. Results indicate that IL-33/ST2 signalling is involved in respiratory syncytial virus (RSV)-induced, Th2-associated airway inflammation but not protective immunity. PMID: 25721734
35. These results suggest that modulation of the ST2L internalization by FAK/GSK3beta might serve as a unique strategy to lessen pulmonary inflammation. PMID: 25472995
36. IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice PMID: 24985397
37. ST2 does not impair the establishment of adult L. sigmodontis worms, but is important for the splenic clearance of microfilariae from peripheral blood. PMID: 24663956
38. Together, these data reveal a cell-intrinsic role for the IL-33/ST2 axis in the regulation of apoptosis in MC, identifying thereby a previously unappreciated pathway supporting expansion of the MC population with inflammation. PMID: 24982172
39. IL-33/ST2 signalling triggers the production of inflammatory mediators contributing to carrageenin-induced inflammation; this reinforces the importance of IL-33/ST2 signalling as a target in innate inflammation and inflammatory pain PMID: 23347081
40. These data further suggested that IL-33/ST2 signaling played a vital role in cancer pain. PMID: 23988433
41. ST2 augments rather than inhibits cytokine release by blood leukocytes and splenocytes exposed to S. pneumoniae or K. pneumoniae, but plays a limited role in host defense during sepsis caused by these pathogens. PMID: 23856919
42. Which was attenuated in the absence of ST2. PMID: 24105680
43. The IL-33 and ST2 suppresses Th1 responses in the livers of BALB/c mice infected with Leishmania donovani. PMID: 24045639
44. Bee venom PLA2-induced innate lymphoid cells & primary Th2 responses were dependent on ST2. The IgE response was largely unaffected by ST2-deficiency, possibly because ST2 is required for primary but not secondary T cell responses. PMID: 24210353
45. The role of ST2 differs between different target tissues: ST2 is dispensable for the development of Th2 response in the sensitized skin, whereas it is a main inducer of Th2 cytokines in asthmatic airways. PMID: 23633023
46. These data suggest IL-33 and its ST2 receptor mediate formalin-induced inflammatory pain PMID: 23523996
47. Mice deficient in IL-33R significantly develop more severe pancreatitis, have greater weight loss, and contain higher viral load compared with wild-type mice. PMID: 23733876
48. ST2 plays a limited anti-inflammatory role during both primary influenza and postinfluenza pneumococcal pneumonia. PMID: 23483993
49. T1/ST2 directs Th2 cell activation and polyfunctionality in allergic bronchopulmonary mycosis. PMID: 22990621
50. Il-33/ST2 activation in HESCS drives an autoinflammatory response that controls the temporal expression of receptivity genes PMID: 23300625

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KEGG: mmu:17082

STRING: 10090.ENSMUSP00000054914

UniGene: Mm.289824