Recombinant Mouse Interleukin-27 receptor subunit alpha (Il27ra)

1. show that IL-27R signaling controls endothelial cells activation and myeloid cell recruitment at early and advanced stages of atherosclerosis. In the absence of IL-27R myeloid cells become hyperactivated, produce pro-inflammatory cytokines and act as more potent antigen presenting cells. PMID: 28536468
2. data suggested that IL-27/IL-27R expression induced by Toxoplasma gondii infection may regulate mast cell-mediated immune response during acute ocular toxoplasmosis in mouse model PMID: 29779048
3. IL-27 signaling in Foxp3(+) Tregs essential for Tregs to control autoimmune inflammation in the central nervous system PMID: 28874534
4. The combination of mutant p53 & IL27RA(-/-) causes spontaneous liver inflammation, steatosis, and fibrosis, whereas either gene alone has no effects on the liver. PMID: 26637970
5. IL-10 production by CD4(+) YFP(+) T cells is controlled systemically during malaria infection through IL-27 receptor signaling that is supported after CD4(+) T cell priming by ICOS signaling. PMID: 26459508
6. The significant expression of IL-27 in TB and the negative influence of IL-27R on T cell function demonstrate the pathway by which this cytokine/receptor pair is detrimental in TB. PMID: 26282876
7. IL-27R-mediated regulation of IL-17 controls the development of respiratory syncytial virus-associated pathogenesis. PMID: 24726498
8. The loss of IL-27R signaling across the whole mouse resulted in reduced viral control and a slight increase in the number of virus-specific CD4 T cells at early stages of viral infection. PMID: 23993651
9. Diminution of the Th1 response in infected Il27ra mice in vivo by neutralization of IL-12p40 attenuated CCR5 expression. PMID: 23536628
10. These findings establish a novel antiatherogenic role for IL-27 receptor signaling, which acts to suppress the production of proinflammatory cytokines and chemokines and to curb the recruitment of inflammatory myeloid cells into atherosclerotic aortas. PMID: 22927332
11. In Th1-dependent autoinflammatory lesions, IL-27Ralpha has a biphasic role in vivo, initially pathogenic, but ultimately playing a protective role by regulating immune responses and attenuating disease. PMID: 21281790
12. Data show that the deletion of Il27ra ameliorates pathology in the pristane-induced SLE model. PMID: 21098093
13. Findings demonstrate the essential role of IL-27R signaling in regulating effector T cell function during malaria infection and reveal a novel pathway that might be amenable to manipulation by drugs or vaccines. PMID: 20631310
14. A novel role is revealed for WSX-1 as an inhibitory regulator of cytokine production and inflammation in Con A-induced hepatitis. PMID: 15004160
15. The requirement for WSX-1 signaling in T helper type 1 cell differentiation is restricted to conditions in which IL-4 is produced. PMID: 15067040
16. demonstrate an important role for WSX-1 signaling in the promotion of type 1 responses and chronic gastrointestinal nematode infection PMID: 15187144
17. A novel role is identified for IL-27/WSX-1 in limiting innate and adaptive components of type 2 immunity at mucosal sites. PMID: 15494513
18. IL-27R signaling is dispensable for the induction of interferon (IFN)-gamma producing antigen-specific CD4 T cells during experimental pulmonary tuberculosis. PMID: 15585875
19. WSX-1 mRNA is markedly up-regulated in inflammatory cells in the CNS PMID: 15850576
20. Surface expression of the IL-27 receptor is low on naive T cells; the highest levels are found on effector and memory CD4+ and CD8+ T cells. PMID: 15944269
21. WSX-1 plays an important role in the down-regulation of airway hyper-reactivity and lung inflammation during the development of allergic asthma through its suppressive effect on cytokine production. PMID: 16081811
22. Whereas IFN-gammaR signals are dispensable for the T-bet-dependent IFN-gamma production, direct IL-27Ralpha signals are critical. PMID: 18178806
23. In contrast to the immunosuppressive role observed in the asthma model, IL-27/WSX-1 topically plays an exacerbating role in the pathogenesis of allergic rhinitis, presumably through differential expression of chemokines. PMID: 19354069
24. Results reveal an interleukin 27-independent function of WSX1 sensitizing natural killer cell-mediated antitumor surveillance. PMID: 19549909
25. an alternatively spliced WSX-1 isoform enables humanine to rescue Alzheimer's disease relevant neuronal death. PMID: 19703422

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KEGG: mmu:50931

STRING: 10090.ENSMUSP00000005601

UniGene: Mm.38386