Recombinant Mouse Interleukin-27 receptor subunit alpha(Il27ra)

Code CSB-CF011644MO
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names Il27ra
Uniprot No. O70394
Alternative Names Il27ra; Tccr; Wsx1; Interleukin-27 receptor subunit alpha; IL-27 receptor subunit alpha; IL-27R subunit alpha; IL-27R-alpha; IL-27RA; Type I T-cell cytokine receptor; TCCR; WSX-1
Species Mus musculus (Mouse)
Expression Region 25-623
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.
Gene References into Functions
  1. show that IL-27R signaling controls endothelial cells activation and myeloid cell recruitment at early and advanced stages of atherosclerosis. In the absence of IL-27R myeloid cells become hyperactivated, produce pro-inflammatory cytokines and act as more potent antigen presenting cells. PMID: 28536468
  2. data suggested that IL-27/IL-27R expression induced by Toxoplasma gondii infection may regulate mast cell-mediated immune response during acute ocular toxoplasmosis in mouse model PMID: 29779048
  3. IL-27 signaling in Foxp3(+) Tregs essential for Tregs to control autoimmune inflammation in the central nervous system PMID: 28874534
  4. The combination of mutant p53 & IL27RA(-/-) causes spontaneous liver inflammation, steatosis, and fibrosis, whereas either gene alone has no effects on the liver. PMID: 26637970
  5. IL-10 production by CD4(+) YFP(+) T cells is controlled systemically during malaria infection through IL-27 receptor signaling that is supported after CD4(+) T cell priming by ICOS signaling. PMID: 26459508
  6. The significant expression of IL-27 in TB and the negative influence of IL-27R on T cell function demonstrate the pathway by which this cytokine/receptor pair is detrimental in TB. PMID: 26282876
  7. IL-27R-mediated regulation of IL-17 controls the development of respiratory syncytial virus-associated pathogenesis. PMID: 24726498
  8. The loss of IL-27R signaling across the whole mouse resulted in reduced viral control and a slight increase in the number of virus-specific CD4 T cells at early stages of viral infection. PMID: 23993651
  9. Diminution of the Th1 response in infected Il27ra mice in vivo by neutralization of IL-12p40 attenuated CCR5 expression. PMID: 23536628
  10. These findings establish a novel antiatherogenic role for IL-27 receptor signaling, which acts to suppress the production of proinflammatory cytokines and chemokines and to curb the recruitment of inflammatory myeloid cells into atherosclerotic aortas. PMID: 22927332
  11. In Th1-dependent autoinflammatory lesions, IL-27Ralpha has a biphasic role in vivo, initially pathogenic, but ultimately playing a protective role by regulating immune responses and attenuating disease. PMID: 21281790
  12. Data show that the deletion of Il27ra ameliorates pathology in the pristane-induced SLE model. PMID: 21098093
  13. Findings demonstrate the essential role of IL-27R signaling in regulating effector T cell function during malaria infection and reveal a novel pathway that might be amenable to manipulation by drugs or vaccines. PMID: 20631310
  14. A novel role is revealed for WSX-1 as an inhibitory regulator of cytokine production and inflammation in Con A-induced hepatitis. PMID: 15004160
  15. The requirement for WSX-1 signaling in T helper type 1 cell differentiation is restricted to conditions in which IL-4 is produced. PMID: 15067040
  16. demonstrate an important role for WSX-1 signaling in the promotion of type 1 responses and chronic gastrointestinal nematode infection PMID: 15187144
  17. A novel role is identified for IL-27/WSX-1 in limiting innate and adaptive components of type 2 immunity at mucosal sites. PMID: 15494513
  18. IL-27R signaling is dispensable for the induction of interferon (IFN)-gamma producing antigen-specific CD4 T cells during experimental pulmonary tuberculosis. PMID: 15585875
  19. WSX-1 mRNA is markedly up-regulated in inflammatory cells in the CNS PMID: 15850576
  20. Surface expression of the IL-27 receptor is low on naive T cells; the highest levels are found on effector and memory CD4+ and CD8+ T cells. PMID: 15944269
  21. WSX-1 plays an important role in the down-regulation of airway hyper-reactivity and lung inflammation during the development of allergic asthma through its suppressive effect on cytokine production. PMID: 16081811
  22. Whereas IFN-gammaR signals are dispensable for the T-bet-dependent IFN-gamma production, direct IL-27Ralpha signals are critical. PMID: 18178806
  23. In contrast to the immunosuppressive role observed in the asthma model, IL-27/WSX-1 topically plays an exacerbating role in the pathogenesis of allergic rhinitis, presumably through differential expression of chemokines. PMID: 19354069
  24. Results reveal an interleukin 27-independent function of WSX1 sensitizing natural killer cell-mediated antitumor surveillance. PMID: 19549909
  25. an alternatively spliced WSX-1 isoform enables humanine to rescue Alzheimer's disease relevant neuronal death. PMID: 19703422

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Subcellular Location Membrane; Single-pass type I membrane protein.
Protein Families Type I cytokine receptor family, Type 2 subfamily
Tissue Specificity Expressed in CD4+ and CD8+ T-cells, B-cells, natural killer cells and macrophages. Highest levels in CD4+ T-cells and natural killer cells. Expression highest in Th0 cells.
Database Links

KEGG: mmu:50931

STRING: 10090.ENSMUSP00000005601

UniGene: Mm.38386

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