Recombinant Mouse Leukocyte antigen CD37(Cd37)

Code CSB-CF713974MO
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names Cd37
Uniprot No. Q61470
Alternative Names
Cd37; Leukocyte antigen CD37; CD antigen CD37
Species Mus musculus (Mouse)
Expression Region 1-281
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Gene References into Functions
  1. CD37 may protect against IgA nephropathy by inhibition of the IL-6 pathway. PMID: 29551516
  2. this study identifies CD37 as a tumor suppressor that directly protects against B cell lymphomagenesis PMID: 26784544
  3. The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model. PMID: 24445867
  4. The cellular defect that underlies poor cellular immune induction in CD37-defcient mice is impaired dendritic cell migration. PMID: 23420539
  5. CD37 was required for the mobility and clustering of alpha(4)beta(1) integrins in the plasma membrane, thus regulating the membrane distribution of alpha(4)beta(1) integrin necessary for activation of the Akt survival pathway PMID: 23150881
  6. CD37 protects against glomerular IgA deposition and renal pathology PMID: 20348240
  7. The influence of CD37 in the early events of T cell receptor signaling demonstrates a regulatory role for CD37 in T cell proliferation. PMID: 14978098
  8. tetraspanin protein CD37 inhibits IgA responses and regulates the anti-fungal immune response. PMID: 19282981

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Subcellular Location Membrane; Multi-pass membrane protein.
Protein Families Tetraspanin (TM4SF) family
Database Links

KEGG: mmu:12493

STRING: 10090.ENSMUSP00000096061

UniGene: Mm.3689

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7505 Fannin St Ste 610-322 Houston, TX 77054, USA
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