Recombinant Mouse Leukosialin (Spn)

1. glycosylation status of CD43 protein on leukemia cells is associated with sensitivity to CTL-mediated cytolysis PMID: 27011118
2. findings demonstrate that CD43 is a major E-selectin ligand in Th17 cells that functions independent of P-selectin glycoprotein ligand-1 PMID: 26700769
3. CD43 may be an important mediator of macrophage lipid homeostasis, thereby affecting macrophage foam cell formation and ultimately atherosclerotic plaque development. PMID: 25524774
4. We have identified a robust physiologic role for CD43 in a relevant animal model and established an important in vivo function for CD43-dependent regulation of IFN-gamma production. PMID: 23585675
5. Results show that while CD43 binding to ezrin-radixin-moesin proteins is crucial for S76 phosphorylation, CD43 movement and regulation of T-cell migration can occur through an ERM-independent, phosphorylation-dependent mechanism. PMID: 21289089
6. study found that the M. tuberculosis Cpn60.2 molecular chaperone is the major mycobacterial surface ligand that interacts with CD43 to stabilize the interaction between M. tuberculosis and the macrophage PMID: 20633027
7. Transient resistance to B16F10 melanoma growth and metastasis in CD43-/- mice. PMID: 11828253
8. CD43 engagement and signaling are involved in the costimulatory and antiapoptotic effects of enzymatically inactive mutant trypanosomal trans-sialidase when it binds highly sialylated mucin CD43 on the T cell surface. PMID: 11994475
9. Cd43 displays dynamic roles in T cell immunity: a positive regulatory role in costimulation and trafficking of T cells to the central nervous system, and a negative regulatory role in the down-modulation of an immune response. PMID: 12055210
10. Delayed onset of experimental autoimmune encephalomyelitis in CD43-deficient immunized mice and in recipients of adoptively transferred CD43-/- cells is characterized by significant reduction of T cell trafficking to the brain and spinal cord. PMID: 14662853
11. Exclusion of the CD43 intracellular region from the immunological synapse is required for CD43 regulation of interleukin-2 production. PMID: 15117976
12. Two functionally distinct populations of small intestinal intraepithelial lymphocytes (IELs) are described that differ according to the expression of a CD43 glycoform. PMID: 15528368
13. CD43 is involved in the binding, uptake, and subsequent growth of Mycobacterium tuberculosis in murine macrophages and in vivo PMID: 16034122
14. That CD43 costimulation was responsible for elevated cytokine/chemokine activity was confirmed at the transcriptional level by real-time PCR for IFN-gamma and CCL5, and by ELISA for IFN-gamma. PMID: 16246302
15. CD43, when modified by a specific set of glycosyltranferases, can function as an E-selectin ligand and therefore potentially mediate activated T cell migration PMID: 16339541
16. These results characterize an important role for CD43 during the activation and expansion of autoreactive MOG-specific CD8+ T cells. PMID: 16890924
17. Recruitment of neutrophils and activated T cells in in vivo models is not influenced by CD43 expression. PMID: 17056577
18. CD43 functions as a signaling molecule, sensing extracellular cues and transducing intracellular signals that modulate T-cell function PMID: 17638845
19. results demonstrate that CD43 regulates Th cell differentiation in vitro and in vivo PMID: 18490738
20. The authors propose that CD43 is involved in the inflammatory response to M. tuberculosis and, through the induction of pro-inflammatory mediators, can regulate apoptosis to control intracellular growth of the bacterium. PMID: 18637079
21. The loss of both PSGL-1 and CD43 led to a further increase in T cell adhesion and proliferation PMID: 19890058

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KEGG: mmu:20737

STRING: 10090.ENSMUSP00000049534

UniGene: Mm.283714