Recombinant Mouse Melanin-concentrating hormone receptor 1 (Mchr1)

1. This study demonstrated that the Neurochemical Heterogeneity Among Lateral Hypothalamic Melanin-Concentrating Hormone Neurons. PMID: 28966976
2. following pups retrieval, MCHR1 knockout mice display a lower level of Fos expression than wild type mice in the ventral tegmental area, and nucleus accumbens PMID: 27617778
3. This study showed that KO of mchr1 mice had significantly higher levels of both punished and non-punished food maintained responding. PMID: 27633558
4. MCH1-Rs regulate the rewarding properties of alcohol through interactions with signaling cascades in the nucleus accumbens shell. PMID: 27044354
5. This study supports the use of the Mchr1-cre mouse for outlining the neuroanatomical distribution and neurochemical phenotype of MCHR1 neurons. PMID: 23605441
6. This study demonistrated that lack of MCH receptor provoked a ventricular size increase and beat frequency of ependymal cilia. PMID: 23708141
7. Mchr1 and Sstr3 are expressed and colocalized within cilia in multiple mouse brain regions, and they form heteromers. PMID: 23029470
8. Disruption of the melanin-concentrating hormone receptor 1 (MCH1R) affects thyroid function PMID: 23024261
9. The elevated basal body temperature and reduction in NREM sleep time resulting from shorter NREM episode durations observed in knockout mice suggests that central MCH(1) receptor has a role in thermoregulation and presumably stabilization of NREM sleep. PMID: 21074567
10. Data show that the melanin-concentrating hormone/MCH1R system is one of the players mediating behavioral and metabolic responses upon increased caloric consumption. PMID: 20411353
11. In melanin-concentrating hormone receptor 1 knock-out mice, long-term synaptic depression was strongly diminished in hippocampus. PMID: 20592115
12. The data indicate that the MCH system is involved in the regulation of PTZ and pilocarpine seizure threshold. PMID: 20709149
13. The gene encoding the mouse melanin-concentrating hormone receptor 1 was isolated and its structural organization and flanking regions were characterized. PMID: 15093132
14. metoprolol completely reversed the tachycardia seen in MCHR1(-/-) mice, suggesting an increased sympathetic tone PMID: 15130877
15. Periplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail PMID: 15590649
16. In summary, the MCHr is not required for ghrelin induced feeding. PMID: 15607734
17. Deletion of MCH1r results in an upregulation of mesolimbic dopamine receptors and norepinephrine transporter, indicating that MCH1r may negatively modulate mesolimbic monoamine function. PMID: 15673672
18. Castration and testosterone treatment on the vasculature in the ventral prostate in adult rats and mice alter expression of this protein. PMID: 15845622
19. Triple-substitution mutants of intracellular loops 1 and 3 can activate calcium mobilization, albeit with lower efficacy or potency. PMID: 15890773
20. Pyramidal neurons in knockout mice revealed significantly decreased NMDA responses. PMID: 15926931
21. These data support the notion that MIZIP might interact with elanin-concentrating hormone receptor 1 (MCHR1) in a cell type specific manner in vivo, suggesting a role in the regulation of MCH signalling in distinct regions of the mammalian brain. PMID: 15950311
22. show that MCHR1 can modulate stress- and anxiety-like behaviors and suggest that this may be due to changes in serotonergic transmission in forebrain regions PMID: 15988472
23. MCHR1 may contribute to the neurobiological mechanisms of conditioned cocaine-induced psychomotor effects, possibly to those underpinning sensitization, and to a lesser extent to those sub-serving acute pharmacological cocaine action. PMID: 16839618
24. the main phenotype displayed by Mchr1 knockout mice was hyperactivity, reduced anxiety, and faster visomotor responses in the absence of nay discernable deficit of sensorimotor and spacial learning abilities PMID: 17270288
25. MCH1 receptor signalling is involved in the development of fatty liver, as well as obesity, in ovariectomized mice PMID: 17519948
26. male MCH-1R knockout mice consume more alcohol than wild-type and heterogenous mice PMID: 17550369
27. Our results do not support the hypothesis of a functional contribution of MCHR1 receptors to the addictive effects of D-amphetamine PMID: 17996928
28. MCH(1) receptor KO mice are hypersensitive to the behavioral and molecular effects of the dopaminergic psychostimulant d-amphetamine and Increased frontal cortical MAPK phosphorylation and c-fos expression. PMID: 18000809
29. These results demonstrate that MCH, in addition to its known role in feeding and weight regulation, plays a critical role in regulating Acb dopamine signaling and related behavioral responses. PMID: 18281019
30. Animals with genetically inactivated melanin-concentrating hormone receptor 1 signaling exhibit altered vigilance state architecture and sleep homeostasis. PMID: 18380672

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KEGG: mmu:207911

STRING: 10090.ENSMUSP00000126191

UniGene: Mm.323523