Recombinant Mouse Melanocyte-stimulating hormone receptor (Mc1r)

1. These data clearly show a new and hitherto unsuspected role for MC1R in noncutaneous solid tissues before birth. PMID: 29316344
2. Collectively, our findings suggest that melanocortin therapy confers a proteinuria reducing and podoprotective effect in proteinuric glomerulopathies via MC1R-independent mechanisms. PMID: 27270328
3. results highlight a central role for MC1R palmitoylation in pigmentation and protection against melanoma PMID: 28869973
4. We conclude that MC1R plays an important role in regulating melanoma growth and morphology PMID: 27028866
5. Activation of Mc1r prevents cholesterol uptake and confers protection against macrophage foam cell formation. PMID: 28450348
6. MC1-mediated effects were reduced, and MC3 anti-inflammatory circuits predominated. Mice bearing a nonfunctional MC1 displayed a transient exacerbation of neutrophil recruitment after global I/R, which diminished by 2 hours. PMID: 26112010
7. MR importantly contributes to diabetes-associated vascular dysfunction by inducing oxidative stress and by increasing the activity of redox-sensitive proteins PMID: 25967696
8. MC1 has an endogenous regulatory function in collagen synthesis and controls the extent of fibrotic stress responses of the skin. PMID: 24698097
9. A melanin-independent interaction between Mc1r and Met signaling pathways is required for hepatocyte growth factor-dependent melanoma. PMID: 24975581
10. In summary, we have identified a new alpha-MSH-MC1R physiologic pathway that reduces HO-induced RPE cell damage, and might minimize the risk of developing AMD. PMID: 24316214
11. Absence of Mc1r does not impair the inflammatory response to UV radiation or the generation of immunosuppression. PMID: 23489427
12. MC1R decrease the inflammation in vitro and vivo, and might be part of a signaling pathway in inflammatory diseases. PMID: 23090482
13. Melanocortin receptors 1 and 5 might mediate inhibitory effects of alpha-melanocyte-stimulating hormone on antigen-induced chronic allergic skin inflammation in IgE transgenic mice. PMID: 22437312
14. MC1R regulates melanoma cell migration via inhibition of syndecan-2 expression. PMID: 22493442
15. Spatiotemporal localization of MC1R and alpha-MSH in cutaneous wounds warrants future investigation into the role of MC1R/alpha-MSH signaling in the inflammatory and fibroproliferative responses to cutaneous injury. PMID: 21378282
16. Data show RNA interference that targets Ube3a in P19 cells caused downregulation of Mc1r and Nr4a2, whereas overexpression of Ube3a results in the upregulation of Mc1r and Nr4a2. PMID: 20571502
17. MC1R contributes to pain of inflammatory origin. PMID: 20856883
18. MC1R protects by a combination of pigmentary and non-pigmentary effects in vivo and when MC1R function is compromised the melanin type in skin is still protective against UVR PMID: 20237490
19. The pigmentation of atopic dermatitis is related to increased levels of alpha-MSH, MC1R (in the skin) and MC3R (in intestines). PMID: 19889022
20. The human receptor efficiently rescued mouse Mc1r deficiency and appeared to be completely resistant to the effect of agouti, suggesting agouti protein may play a role in human pigmentary variation. PMID: 11689486
21. Antagonist and agonist activities of the mouse agouti protein fragment (91-131) at the melanocortin-1 receptor. PMID: 11693171
22. the function of the MC1 and MC4 receptors can be positively modulated by metal ions acting both as partial agonists and as potentiators for other agonists PMID: 12244039
23. the melanocortin-1 receptor (Mc1r) gene mediates kappa-opioid analgesia in female mice only PMID: 12663858
24. Regulation of melanocortin 1 receptor mRNA and protein levels. PMID: 14500544
25. there was a significant difference in anesthetic requirements between mice with homozygous melanocortin 1 receptor and control heterozygous mice PMID: 15277941
26. UV-induced expression of POMC and MC1R is dependent on the p-38-activated upstream stimulating factor-1 PMID: 15358786
27. The The expression of the Melanocortin Receptor 1 genes in the epidermis and dermis of the dorsal skin was surveyed from 13 d old embryos to 5.5 d old neonates. PMID: 15541020
28. Melanocortin 1 receptor signaling is regulated by GRK2 and GRK6, which may be important determinants of skin pigmentation. PMID: 15650023
29. C57BL/6-Mc1r(e/e) mutant mice and human redheads--both with non-functional MC1Rs--display reduced sensitivity to noxious stimuli and increased analgesic responsiveness to the mu-opioid selective morphine metabolite, M6G. PMID: 15994880
30. ultraviolet light potently induces expression of MSH in keratinocytes, but fails to stimulate pigmentation in the absence of functional MC1R in red/blonde-haired Mc1r(e/e) mice PMID: 16988713
31. These findings offer insights into the transcriptional nature of the response to ultraviolet rays (UV) in the skin and provide a molecular framework for the mechanisms by which melanocytes and the Mc1r independently afford protection against UV radiation. PMID: 17222061
32. Results suggest that the Mc1r(e) mutation affects the proliferation and differentiation of melanocytes and l-tyrosine rescues the reduced proliferative and differentiative activities. PMID: 17532540
33. two genes interact epistatically: the phenotypic effects of Mc1r are visible only in genetic backgrounds containing the derived Agouti allele PMID: 17696646
34. These data identify the NR4A receptor family as potential mediators of an MC1R-coordinated DNA damage response to ultraviolet rays exposure in melanocytic cells. PMID: 18292087
35. These findings demonstrate that alpha-MSH suppression of lipopolysaccharide-induced inflammatory activity in macrophages requires expression of MC1r. PMID: 18388300
36. molecular effects elicited by MC1R ligands that may function during development and may affect skin cancer risk PMID: 19174519

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KEGG: mmu:17199

STRING: 10090.ENSMUSP00000095929

UniGene: Mm.324942