Recombinant Mouse Neuromedin-U receptor 2 (Nmur2)

Code CSB-CF803966MO
MSDS
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names
Nmur2
Uniprot No.
Alternative Names
Nmur2; Neuromedin-U receptor 2; NMU-R2
Species
Mus musculus (Mouse)
Expression Region
1-395
Target Protein Sequence
MGKLENASWIHDSLMKYLNSTEEYLAYLCGPKRSDLSLPVSVVYALIFVVGVIGNLLVCL VIARHQTLKTPTNYYLFSLAVSDLLVLLLGMPLEVYELWHNYPFLFGPVGCYFKTALFET VCFASILSVTTVSIERYVAIVHPFRAKLESTRRRALRILSLVWSFSVVFSLPNTSIHGIK FQQFPNGSSVPGSATCTVTKPIWVYNFIIQATSFLFYILPMTLISVLYYLMGLRLKRDES LEADKVTVNIHRPSRKSVTKMLFVLVLVFAICWTPFHVDRLFFSFVDEWTESLAAVFNLI HVVSGVFFYLSSAVNPIIYNLLSRRFRAAFRNVVSPSCKWCHPQHRPQGPPAQKVIFLTE CHLVELTEDAGPQFPCQSSIHNTQLTTVPCVEEVP
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Receptor for the neuromedin-U and neuromedin-S neuropeptides.
Gene References into Functions
  1. The present data do not support a significant contribution of NMUR2 to the development of hypersensitivity after nerve injury or tissue inflammation PMID: 23349076
  2. Data show that deficiency of neuromedin receptors NMUR1 and NMUR2 had no impact on arthritis severity. PMID: 22314006
  3. The circadian rhythm of neuromedin U expression in the suprachiasmatic nucleus does not drive a circadian rhythm of corticotrophin-releasing factor in the paraventricular nucleus. PMID: 15733101
  4. molecular basis of the NMU2R regulation of food intake and body weight in mice PMID: 16781063
  5. Plays a more significant role in central pain processing than other brain functions including stress/anxiety and regulation of feeding. PMID: 17030627
  6. the pro-nociceptive effects of neuromedin U in mice appear to be mediated through NMUR2, not NMUR1 PMID: 17379411
  7. Long-term central NMU treatment reduces body weight, food intake, and adiposity and that central NMUR2 signaling is required for these effects in female but not male mice. PMID: 19584200

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Tissue Specificity
Expressed primarily in brain tissues, more specifically in medulla and spinal cord. Widespread distribution in peripheral tissues.
Database Links
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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