Recombinant Mouse P2Y purinoceptor 2 (P2ry2)

1. The P2Y2R enhances Ubiquitin-Proteasome System activity by increasing the subunits expression beta 5 and beta 1. PMID: 27768902
2. The results of this study suggest that P2Y2Rs contribute to the development of salivary gland inflammation in IL-14alphaTG mice and may also contribute to autoimmune sialadenitis in humans. PMID: 29297959
3. Our results clearly demonstrate the involvement of P2Y2R subtypes in the pathogenesis of fibrotic lung diseases in humans and mice and hence support the development of selective P2Y2R antagonists for the treatment of IPF. PMID: 28415591
4. knockdown of P2Y2R retarded cyst expansion in vitro and prevented ATP- and HIF-1alpha-dependent cyst growth. In conclusion, P2Y2R mediates ATP-dependent cyst growth and is transcriptionally regulated by HIF-1alpha. PMID: 27565965
5. P2Y2R is an inhibitor of arterial intimal calcification, regulating the osteoblastic trans-differentiation of smooth muscle cells through P2Y2R-mediated Runx2 antagonism. PMID: 28038380
6. These findings are consistent with the notion that the primary action of P2Y2 receptor signalling in bone is to regulate extracellular ATP levels. PMID: 28420708
7. Results demonstrate that P2Y2 contributes to response properties of cutaneous afferents, as P2Y2 deletion reduces responsiveness of conventional unmyelinated polymodal afferents to heat and appears to result in the acquisition of mechanical responsiveness in a subset of TRPV1-expressing afferents. PMID: 27393251
8. This study suggests that P2Y2 may participate in cardiomyopathy in mdx mice. PMID: 27220808
9. Extracellular ATP induces vascular inflammation and atherosclerosis via activation of P2Y2. PMID: 27339459
10. Endothelial cell-specific P2Y2R deficiency reduces atherosclerotic burden and promotes plaque stability in ApoE(-/-) mice through impaired macrophage infiltration acting together with reduced matrix metalloproteinase-2 activity and increased smooth muscle cell migration. PMID: 27856454
11. Calcium-mediated purinergic receptors regulate the migration and phagocytic ability of microglia during post-natal brain development. PMID: 25575683
12. expression of P2Y(2) receptor in peripheral sensory neurons that innervate the injured tissue and the activation of P2Y receptors contributes to mechanical allodynia following inflammation PMID: 26062804
13. In P2Y1R (-/-) mice, the expression of P2Y2 receptor in muscle was reduced by over 50 %, as compared to P2Y1R (+/+) mice. PMID: 26036470
14. gene deficiency restricted to hematopoietic tissues results in longer survivak after GvHD PMID: 26538394
15. P2Y2R deficiency does not alter baseline collateral vessel formation but does significantly impair collateral maturation, with resultant persistent limb ischemia despite enhanced angiogenesis. PMID: 25088742
16. P2Y2-/- mice are less susceptible to mount an autoimmune response against IRBP PMID: 25692550
17. P2Y2 and Gq/G11 are required for basal endothelial NO formation, vascular tone, and blood pressure. PMID: 26168216
18. P2Y2-mediated increase of cytoplasmic Ca(2+) concentration down-regulates the expression of NCC. PMID: 24463702
19. P2Y2 receptors play important roles in bone marrow cell differentiation and mineralization as well as in bone cell mechanotransduction, leading to an osteopenic phenotype in P2Y2 knockout mice. PMID: 25268784
20. P2Y2R has a role in the skin wound-healing process in mouse models PMID: 24816122
21. Thus, P2Y2R activation protects cardiomyocytes from hypoxia in vitro and reduces post-ischemic myocardial damage in vivo. PMID: 23828651
22. UTP-induced migratory responses required for salivary gland acinar cell self-organization are mediated by the P2Y2R. PMID: 24760984
23. Osteoblasts can regulate their mechanosensitivity through P2Y2R activation leading to increased cell stiffness. PMID: 24696143
24. Mice deficient in P2Y2 or lacking ATP secretion from platelets show strongly reduced tumor cell metastasis PMID: 23810565
25. up-regulation of P2Y2Rs in primary cortical neurons under pro-inflammatory conditions can promote cofilin-dependent neurite outgrowth, a neuroprotective response that may be a novel pharmacological target in the treatment of neurodegenerative diseases. PMID: 23550835
26. Stimulation of astrocytic P2Y1R receptors significantly reduces brain injury after acute trauma and is mediated by the inositol 1,4,5-trisphosphate (IP3) receptor-signaling pathway. PMID: 23046422
27. Purinergic P2Y receptors promote neutrophil infiltration and hepatocyte death in mice with acute liver injury. PMID: 22974709
28. Although C/EBPbeta was sufficient to induce P2Y(2) transcription, the effect of C/EBPbeta and NF-kappaB p65 on receptor transcription was synergistic. PMID: 22742194
29. Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent. PMID: 22199395
30. P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent. PMID: 22057273
31. genetic deletion of P2Y2-R offers significant resistance to the development of Li-induced polyuria, without altering blood Li levels and renal accumulation of Li, and suppression of PGE2 production PMID: 21975874
32. These results indicate that the P2Y(2) receptor mediates uridine-5'-triphosphate cardioprotection, in vivo. PMID: 21839729
33. Systemic activation of P2Y(2) receptors lowers blood pressure and inhibits renal sodium reabsorption. PMID: 21613580
34. role in chondrocyte mechanotransduction PMID: 21520257
35. Data show that tlt and mlh mutations uncouple Otopetrin 1 from inhibition of P2Y receptor function. PMID: 21236346
36. Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-kappaB. PMID: 21464294
37. P2Y(2) R appears to be involved in asthmatic airway inflammation PMID: 20880147
38. Data show that autocrine purinergic receptor P2Y(2), or P2Y(12) signaling amplifies and translates chemotactic cues into directional motility. PMID: 20664064
39. Control of ENaC by purinergic signaling (P2Y2) is necessary for aldosterone escape. PMID: 20813869
40. Eosinophil accumulation, a distinctive feature of lung allergic inflammation, is defective in ovalbumin (OVA)-treated P2Y2 receptor-deficient mice compared with OVA-treated wild type animals. PMID: 20720203
41. Neutralizing intrapulmonary ATP levels or blocking airway P2Y2 receptors on lung neutrophils and macrophages inhibits smoke-induced lung inflammation and confers protection from the development of emphysema. PMID: 20519655
42. These results support involvement of P2Y(2) receptors in bladder sensation, suggesting an important contribution to bladder neuron excitability and hypersensitivity. PMID: 20147562
43. study shows that P2Y2 receptors are expressed in cumulus cell-enclosed oocytes, and that their stimulation opens at least two different types of ion channels PMID: 12193392
44. Knock-out mice reveal tissue-specific roles of P2Y receptor subtypes in different epithelia. PMID: 12644577
45. Both the P2Y2 and P2Y4 receptors are present in the luminal membrane of mouse distal colonic mucosa, and stimulation of these receptors leads to potassium ion secretion. PMID: 15718265
46. functional interaction between endogenous P2Y2 receptor and TRPV1 channels could explain the ATP-induced pain PMID: 16133936
47. P2Y(2) has a role as a morphogen receptor that potentiates neurotrophin signaling in neuronal development and regeneration PMID: 16365320
48. The role of P2Y2 and P2Y4 receptors in peritoneal macrophage calcium signaling is reported. PMID: 16980298
49. I(Cl.UTP) is due to the activation of CFTR Cl- channels through Gq/11-coupled P2Y2 receptor-PLC-PKC signaling and ATP hydrolysis in mouse heart PMID: 17291397
50. oncogenic potential of P2RY2 was confirmed in vitro with the focus formation assay as well as soft agar-growth assay, and also in vivo with a tumorigenicity assay in nude mice. PMID: 17382903

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KEGG: mmu:18442

STRING: 10090.ENSMUSP00000036765

UniGene: Mm.3000