Recombinant Mouse Vesicle-associated membrane protein 8(Vamp8)

Code CSB-CF025786MO
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. O70404
Storage Buffer Tris-based buffer,50% glycerol
Species Mus musculus (Mouse)
Sequence MEEASGSAGNDRVRNLQSEVEGVKNIMTQNVERILSRGENLDHLRNKTEDLEATSEHFKTTSQKVARKFWWKNVKMIVIICVIVLIIVILIILFATGTIPT
Source in vitro E.coli expression system
Gene Names Vamp8
Protein Names Recommended name: Vesicle-associated membrane protein 8 Short name= VAMP-8 Alternative name(s): Endobrevin Short name= Edb
Expression Region 1-101
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (By similarity). Also required for dense-granule secretion in platelets (By similarity). Plays also a role in regulated enzyme secretion in pancreatic acinar cells
Subcellular Location Lysosome membrane, Single-pass type IV membrane protein, Late endosome membrane, Single-pass type IV membrane protein, Early endosome membrane, Single-pass type IV membrane protein, Cell membrane, Single-pass type IV membrane protein
Protein Families Synaptobrevin family
Tissue Specificity Expressed abundantly in the kidney, less in the liver, brain, kidney, heart, lung, pancreas and placenta.
Database Links

KEGG: mmu:22320

STRING: 10090.ENSMUSP00000059501

UniGene: Mm.1838

Pathway Autophagy

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