Recombinant Rat 5-hydroxytryptamine receptor 2C (Htr2c)

1. Injection of a highly selective 5-HT2C receptor agonist, AR231630, into the ventral tegmental area (VTA) is sufficient to inhibit the expression of amphetamine-induced and basal locomotor activity as well as food intake in rats. Blockade of the anorexic effect of peripheral AR231630 on feeding by intra-VTA 5-HT2C receptor antagonist SB24208 injections suggests the involvement of 5-HT2C receptors in these effects. PMID: 29555337
2. This study demonstrated that the proportion of 5-HT2C-R-expressing striatal neurons was 23% (dorsolateral caudate-putamen), 37% (ventromedial caudate-putamen), 53% (nucleus accumbens-core), and 49% (nucleus accumbens-shell). PMID: 27252352
3. Knockdown of 5-HT2C in the amygdala decreases neuronal activity and inhibits neuropathic-pain-related behaviors. PMID: 28011743
4. Results demonstrate that the incubation of cue reactivity during prolonged abstinence from cocaine self-administration is associated with lower potency of the selective 5-HT2CR agonist WAY163909 to suppress cue reactivity, with no evident change in agonist efficacy PMID: 26926963
5. These findings reveal a 5-hydroxytryptamine-mediated mechanism underlying the programming of susceptibility to obesity. PMID: 26769798
6. the activation of 5-HT2A/C receptors reduced Glycine receptor current, possibly through interfering with cytoskeleton-dependent trafficking or clustering of Glycine receptors. PMID: 26371055
7. Study suggested that there is an interactive relationship between the medial prefrontal cortex 5-HT2AR and 5-HT2CR, and that a 5-HT2AR:5-HT2CR imbalance may be a functionally relevant mechanism underlying motor impulsivity PMID: 26120876
8. Study demonstrates that the GHS-R1a/5-HT2C receptor interaction translates into a biologically significant modulation of ghrelin's orexigenic effect PMID: 25727097
9. This study showed that Serotonin-2C and -2a receptor co-expression on cells in the rat medial prefrontal cortex PMID: 25818050
10. During nicotine withdrawal, 5-HT2C receptor mRNA is decreased in hippocampus. PMID: 26031442
11. 5-HT2C expression was postnatally increased in the suprachiasmatic nucleus and 5-HT-induced Ca(2+) mobilisations were amplified in differentiated SCN2.2YC cells and developed suprachiasmatic nucleus neurons. PMID: 24531181
12. Suggest that TNF-mediated decrease in the expression of the serotonin receptor 2c gene may contribute to the pathophysiology of disc herniation. PMID: 25141845
13. Results are consistent with the hypothesis that the effect of the 5-HT2C receptor agonists on progressive ratio schedule performance is mediated by an impairment of motor capacity rather than by a reduction of the incentive value of the food reinforcer. PMID: 25134499
14. demonstrate the homodimeric structure of 5-HT2C receptors endogenously expressed in their native cellular environment, and identifies the homodimer as a functional signaling unit. PMID: 25609374
15. High cocaine cue reactivity measured as appetitive approach behavior correlates with lower 5-HT2CR protein expression in the medial prefrontal cortex and blunted sensitivity to the suppressive effects of the selective 5-HT2CR agonist WAY163909. PMID: 24618688
16. Epileptogenesis induced early adaptive changes and reorganization in the 5-HT2C receptor systems in the dentate gyrus. PMID: 24935789
17. In an UNC1-induced stress model, 5-HT2cR expression and activation was found in brain areas involved in feeding control. PMID: 24269295
18. Genetic loss of the medial prefrontal cortex 5-HT2C receptor induces impulsive action in cocaine dependent animals. PMID: 23939424
19. [(125)I](+/-)4-iodo-2,5-dimethoxyphenyl-isopropylamine would label multiple conformations of both 5-HT2A and 5-HT2C receptors in rat brain PMID: 23864045
20. as compared with Low Impulsivity animals, HI rats were characterized by decreased DA D2R levels in the NAcb shell and the VTA, as well as increased 5-HT2cR level in the OFC. HI rats displayed higher level of zif268 in the NAcbS, NAcbC, and DMS. PMID: 23632436
21. 5-HT2CR is probably an important factor underlying the development of tail spasticity after spinal cord injury by increasing the excitability of both motoneurons and interneurons. PMID: 23337537
22. Results suggest that ligands acting on HTR2C likely modulate cocaine-induced locomotion via a common mechanism to influence dopamine-dependent circuitry. PMID: 23201361
23. 5HTR2C function was down-regulated not only by the amount of 5HTR2C receptor expression, but also by alternative splicing in contusive spinal cord injuries. PMID: 23123772
24. The current data indicate that expression of 5-HT(2C)R mRNA in discrete brain sites is sensitive to physical activity status of the organism. PMID: 23049953
25. a distinct multiprotein complex links 5-hydroxytryptamine-activated intracellular signaling events with NMDA-mediated functional activity PMID: 22291020
26. These results suggest that adaptations of the 5-HT system, especially the upregulation of 5-HT(2C) receptors in the ACC(S) , are involved in the development of enhanced voluntary alcohol-drinking behavior. PMID: 22512261
27. rs3813929 (-759C/T) is established as a functional polymorphism with disruption of DNA-protein interactions as a mechanism by which HTR2C expression is perturbed leading to an influence on antipsychotic-induced weight gain. PMID: 21391883
28. Results reveal a novel role of the 5-HT(2C)R in the dorsal striatum in the expression of instrumental escape deficits produced by uncontrollable stress PMID: 21958863
29. Data show that electroacupuncture activates supraspinal serotonin neurons to release 5-HT, which acts on spinal 5-HT1AR but not 5-HT2CR to inhibit hyperalgesia. PMID: 21556842
30. In the periaqueductal gray, 5-HT2C serotonin receptors are preferentially involved in the regulation of defensive behaviors related to anxiety, but not panic. PMID: 20850460
31. 5-HT(2C)R colocalizes in dopamine and GABA ventral tegmental area neurons which project to the nucleus accumbens PMID: 21687728
32. Genetic disruption of serotonin 5-HT2C receptor function does not alter the motivation to respond for food. PMID: 20624416
33. Findings argue against the hypothesis that 5-HT2cR editing efficiency is regulated by extracellular serotonin levels. PMID: 20948451
34. In summary, 5-HT(2B) and 5-HT(2C) receptors on motoneurons become constitutively active after injury and ultimately contribute to recovery of motoneuron function and emergence of spasms. PMID: 20980537
35. 5-HT2C receptors may generate dyskinesia from associative/limbic territories. PMID: 20447448
36. data indicate that 2C receptor signaling activates a diffuse neural network and suggest that the arcuate and the raphe magnus neurons that express c-Fos after lipopolysaccharide (LPS) are not necessary for LPS anorexia PMID: 19782661
37. These studies implicate the role of 5-HT(7), 5-HT(2C), and 5-HT(1A) receptors in the improvement of cognitive dysfunction of relevance to schizophrenia. PMID: 19629447
38. DOI, an agonist of 5-HT2A/2C serotonin receptor, alters the expression of cyclooxygenase-2 in the rat parietal cortex. PMID: 12369737
39. expression of the serotonin-2c receptor gene may be modulated by dietary fat in OM rats PMID: 12429884
40. We describe tyrosine kinase receptor regulation of a GPCR via MAP kinase. Insulin reduced the activity of the 5-HT2C receptor in choroid plexus cells which was blocked by the MAP kinase kinase (MEK) inhibitor, PD 098059 PMID: 12795815
41. stimulation of 5-HT(2A/2C) receptors facilitates the capsaicin-evoked release of substance P-like immunoreactivity in the dorsal horn PMID: 14499940
42. The majority of tuberomamillary neurones express NCX1, NCX2 and NCKX3. Serotonin 2C receptor-mRNA was detected in 70% while 5-HT2A mRNA was found in only 10% of TM neurones. NCX1-mRNA was present in all neurones expressing the 5-HT2C receptor PMID: 14535948
43. Compared to the 5-HT2A receptor subtype in developing rat brain, the 5-HT2C receptor is already present at a high level at postnatal day 3, increasing only slightly during further postnatal development; it may modulate neuronal plasticity. PMID: 14689478
44. Data show that the 5-hydroxytryptamine 2C receptor gene is expressed by retinal neurons, some of which represent third-order neurons, either amacrine or ganglion cells. PMID: 15193431
45. The present data give anatomical support to a previous hypothesis that proposed a negative-feedback loop involving reciprocal connections between GABAergic interneurons bearing 5-HT2A/2C receptors and 5-HT neurons in the dorsal raphe. PMID: 15652696
46. The functional significance of lys at helix 4.45 and ser or cys at helix 7.45 in the 5-HT2C receptor was tested by site-directed mutagenesis of Caenorhabditis elegans 5-HT2ce and rat 5-HT2C. PMID: 15663485
47. 5-HT2C receptors inhibit nigrostriatal dopaminergic transmission. The results also suggest that the nigrostriatal system is regulated 5-HT2C receptors localized in the dorsal striatum. PMID: 15668911
48. 5-HT2C receptor in the brain has a functional regulatory role in the pancreatic regeneration. PMID: 16010984
49. Medial parabrachial nucleus neuronsmediate anorexia through 5HT2C receptors. PMID: 16343451
50. Physical interaction of PTEN with a region in the third intracellular loop (3L4F) of the serotonin 5-HT2C receptor (5-HT2cR, formerly 5-HT1c receptor) in cell cultures. PMID: 16474401

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KEGG: rno:25187

STRING: 10116.ENSRNOP00000060345

UniGene: Rn.9935