HTR2C, recognized as the 5-hydroxytryptamine 2C receptor, is a type of G protein-coupled receptor that is chiefly expressed within the brain. It is intricately linked to physiological processes such as mood, appetite, and stress responses. The receptor's mechanism of action includes binding to serotonin, which triggers the G protein-coupled signaling cascade and subsequently modulates the excitability of neurons. Given its influence on the regulation of mood, appetite, and the body's stress response, along with its impact on insulin sensitivity and blood glucose balance, HTR2C has emerged as a promising target for drug development. Researchers are keen on exploring its potential for understanding drug effectiveness and pharmacokinetics.
HTR2C Recombinant Monoclonal Antibody (CSB-RA616248A0HU)
Validated Data
Western Blot
Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate
All lanes: HTR2C antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52, 29 kDa
Observed band size: 75 kDa
IHC image of CSB-RA616248A0HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
The following HTR2C reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
HTR2C Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA009358 | HTR2C Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA009359 | HTR2C Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA974667 | HTR2C Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-RA616248A0HU | HTR2C Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
HTR2C Proteins for Pan troglodytes (Chimpanzee)
Code | Product Name | Source |
---|---|---|
CSB-CF702440EQV | Recombinant Pan troglodytes 5-hydroxytryptamine receptor 2C (HTR2C) | in vitro E.coli expression system |
CSB-YP702440EQV1 CSB-EP702440EQV1 CSB-BP702440EQV1 CSB-MP702440EQV1 CSB-EP702440EQV1-B |
Recombinant Pan troglodytes 5-hydroxytryptamine receptor 2C (HTR2C), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HTR2C Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Source |
---|---|---|
CSB-CF736788DO | Recombinant Dog 5-hydroxytryptamine receptor 2C (HTR2C) | in vitro E.coli expression system |
CSB-YP736788DO1 CSB-EP736788DO1 CSB-BP736788DO1 CSB-MP736788DO1 CSB-EP736788DO1-B |
Recombinant Dog 5-hydroxytryptamine receptor 2C (HTR2C), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HTR2C Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF010889MO | Recombinant Mouse 5-hydroxytryptamine receptor 2C (Htr2c) | in vitro E.coli expression system |
CSB-YP010889MO1 CSB-EP010889MO1 CSB-BP010889MO1 CSB-MP010889MO1 CSB-EP010889MO1-B |
Recombinant Mouse 5-hydroxytryptamine receptor 2C (Htr2c), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HTR2C Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-CF010889RA | Recombinant Rat 5-hydroxytryptamine receptor 2C (Htr2c) | in vitro E.coli expression system |
CSB-YP010889RA1 CSB-EP010889RA1 CSB-BP010889RA1 CSB-MP010889RA1 CSB-EP010889RA1-B |
Recombinant Rat 5-hydroxytryptamine receptor 2C (Htr2c), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HTR2C Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF010889HU | Recombinant Human 5-hydroxytryptamine receptor 2C (HTR2C) | in vitro E.coli expression system |
CSB-YP010889HU1 CSB-EP010889HU1 CSB-BP010889HU1 CSB-MP010889HU1 CSB-EP010889HU1-B |
Recombinant Human 5-hydroxytryptamine receptor 2C (HTR2C), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |