Recombinant Rat Activin receptor type-1C(Acvr1c)

Code CSB-CF001259RA
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P70539
Storage Buffer Tris-based buffer,50% glycerol
Species Rattus norvegicus (Rat)
Sequence LKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVSKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITQHLPTASPDAPRLGPTELTVVITVPVCLLSIAAMLTIWACQDRQCTYRKTKRHNVEEPLAEYSLVNAGKTLKDLIYDATASGSGSGPPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMVKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCDTCAIADLGLAVKHDSIMNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGLVEEYQLPYYDMVPSDPSIEEMRKVVCDQKLRPNLPNQWQSCEALRVMGRIMRECWYANGAARLTALRVKKTISQLCVKEDCKA
Source in vitro E.coli expression system
Gene Names Acvr1c
Protein Names Recommended name: Activin receptor type-1C EC= 2.7.11.30 Alternative name(s): Activin receptor type IC Short name= ACTR-IC Activin receptor-like kinase 7 Short name= ALK-7
Expression Region 26-493
Tag Info N-terminal 10xHis-tagged
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
Tissue Specificity Expressed in brain, kidney, lung, liver, testis, ovary, adrenal gland, heart, prostate, gastrointestinal tract, and spleen. Distributed throughout both adult and embryonic central nervous system and pancreatic islet cells.
Database Links

KEGG: rno:245921

STRING: 10116.ENSRNOP00000056047

UniGene: Rn.10580

Pathway TGF-beta signaling pathway
Signaling pathways regulating pluripotency of stem cells

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