Recombinant Xenopus laevis Fibroblast growth factor receptor 2(fgfr2)

Code CSB-CF008645XBE
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. Q03364
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Species Xenopus laevis (African clawed frog)
Sequence TIARPSYSMVDDTTPEPEEPPAKYQISKADVFPVLPGEPLDLRCPLADGPLVTWTKDGAKLEVNNRTLIVRTYLQIKESTTRDSGLYACSVLKNSHFFHVNVTEASSSGDDEDDNDGSEDFTNDNNNIRAPYWTNTEKMEKKLHAVSAANTVKLRCPAREPHPSNEWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGIYTCIVENEHGSINHTYHLDVIERSSHRPILQAGLPANTTAVVGGDAEFVCKVYSDAQPHIRWVRYIEKNGSRFGVDGLPYFKVLKAAGVNVTDEEIEVLYVRNVSFEDAGEYTCIAGNSIGISQHSAWLTVHPAPVNPLEDNPVPYYMEIGIYSTGIFIIFCMVVVCVVCRMRQGAKKKKNFTGPPVHKLTKRIPLHRQVTVSADSSSSMNSTTPLVRITTRLLNSTDAMPLANVSEYELPHDPMWEFSRDKLTLGKPLGEGCFGQVVMAEALGIDKERPKESVTVAVKMLKDNATEKDLADLVSEMEMMKMIGKHKNIINLLGACTQGGTLYVIVEYAAKGNLRQYLRARRPLEMEYSFDVTRVPDEQMTFKDLVSCTYQIARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDVNNIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAIPSHRPTFKQLVEDLDRILTLTTNEEYLDLSAPLEQYSPSFPDSSCSASSSSGDDSVFSPDPMPHDPCLPKFQHVNGVVKT
Source in vitro E.coli expression system
Gene Names fgfr2
Protein Names Recommended name: Fibroblast growth factor receptor 2 Short name= FGFR-2 EC= 2.7.10.1
Expression Region 15-813
Tag Info N-terminal 10xHis-tagged
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1 (By similarity).
Subcellular Location Cell membrane, Single-pass type I membrane protein, Golgi apparatus, Cytoplasmic vesicle
Protein Families Protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily
Tissue Specificity Expressed in the anterior neural plate in early neurula stage embryos. Later in development, the protein is also expressed in the eye anlagen, midbrain-hindbrain boundary and otic vesicle.
Database Links

UniGene: Xl.16135

Pathway MAPK signaling pathway
PI3K-Akt signaling pathway
Regulation of actin cytoskeleton
Ras signaling pathway
Signaling pathways regulating pluripotency of stem cells
Rap1 signaling pathway
Endocytosis

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