FGFR2, fibroblast growth factor receptor 2, alias FGFRβ, Bek, CFD1, etc. FGFR2 is a transmembrane receptor tyrosine kinase, encoded by its own gene in human cells, which plays a role mainly in embryonic development, tissue regeneration, cell proliferation and migration, etc. The mechanism of action of FGFR2 involves binding to multiple fibroblast growth factor (FGF) ligands, such as FGF1, FGF2, FGF4, FGF5, etc., and thus activating its intrinsic tyrosine kinase activity, initiating downstream signaling pathways, such as RAS/ FGF5. The mechanism of action of FGFR2 involves binding to a variety of fibroblast growth factor (FGF) ligands, such as FGF1, FGF2, FGF4, FGF5, etc., which then activates its intrinsic tyrosine kinase activity and initiates downstream signaling pathways, such as RAS/RAF/MEK/ERK, PI3K/AKT, etc.
The significance of FGFR2 is very broad in biology, which is involved in the regulation of a variety of cellular processes, including cell proliferation, differentiation, migration and survival. The signaling pathway of FGFR2 is closely related to physiological and pathological processes such as tissue development, wound healing, tumor growth, and angiogenesis.Abnormal function of FGFR2 has been associated with a wide range of diseases, especially with certain types of cancers, such as breast cancer, gastric cancer, and non-small cell lung cancer. In tumors, mutation or overexpression of FGFR2 may lead to uncontrolled cell proliferation and tumor angiogenesis, promoting tumor invasion and metastasis. Therefore, FGFR2 is a potential target in tumor therapy, and inhibitors against FGFR2 are being developed for the treatment of related cancers.
FGFR2 Recombinant Monoclonal Antibody (CSB-RA154582A0HU)
Validated Data
Western Blot
Positive WB detected in: Rat Brain whole cell lysate, Rat Lung whole cell lysate, Mouse Brain whole cell lysate
All lanes: FGFR2 Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 93, 87, 93, 77, 92, 89, 86, 29, 80, 93, 97, 92, 41, 80, 80, 77, 80 kDa
Observed band size: 145 kDa
The following FGFR2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
FGFR2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA008645GA01HU | FGFR2 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA077444 | FGFR2 Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA000992 | FGFR2 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA449267 | FGFR2 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA151107 | FGFR2 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA008645LA01HU | FGFR2 Antibody | Human | ELISA, IHC |
CSB-PA008645LB01HU | FGFR2 Antibody, HRP conjugated | Human | ELISA |
CSB-PA008645LC01HU | FGFR2 Antibody, FITC conjugated | Human | |
CSB-RA154582A0HU | FGFR2 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB |
CSB-RA008645MA1HU | FGFR2 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
FGFR2 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA008645XA01DIL | fgfr2 Antibody | Danio rerio (Zebrafish) (Brachydanio rerio) | ELISA, WB (ensure identification of antigen) |
FGFR2 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Source |
---|---|---|
CSB-YP008645DIL CSB-EP008645DIL CSB-BP008645DIL CSB-MP008645DIL CSB-EP008645DIL-B |
Recombinant Danio rerio Fibroblast growth factor receptor 2 (fgfr2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGFR2 Proteins for Pleurodeles waltl (Iberian ribbed newt)
Code | Product Name | Source |
---|---|---|
CSB-YP008645EWZ CSB-EP008645EWZ CSB-BP008645EWZ CSB-MP008645EWZ CSB-EP008645EWZ-B |
Recombinant Pleurodeles waltl Fibroblast growth factor receptor 2 (FGFR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGFR2 Proteins for Dugesia japonica (Planarian)
Code | Product Name | Source |
---|---|---|
CSB-YP008645DMU CSB-EP008645DMU CSB-BP008645DMU CSB-MP008645DMU CSB-EP008645DMU-B |
Recombinant Dugesia japonica Fibroblast growth factor receptor 2 (FGFR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGFR2 Proteins for Notophthalmus viridescens (Eastern newt) (Triturus viridescens)
Code | Product Name | Source |
---|---|---|
CSB-YP008645NEO CSB-EP008645NEO CSB-BP008645NEO CSB-MP008645NEO CSB-EP008645NEO-B |
Recombinant Notophthalmus viridescens Fibroblast growth factor receptor 2 (FGFR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGFR2 Proteins for Xenopus laevis (African clawed frog)
Code | Product Name | Source |
---|---|---|
CSB-CF008645XBE | Recombinant Xenopus laevis Fibroblast growth factor receptor 2 (fgfr2) | in vitro E.coli expression system |
CSB-YP008645XBE1 CSB-EP008645XBE1 CSB-BP008645XBE1 CSB-MP008645XBE1 CSB-EP008645XBE1-B |
Recombinant Xenopus laevis Fibroblast growth factor receptor 2 (fgfr2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGFR2 Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-CF008645CH | Recombinant Chicken Fibroblast growth factor receptor 2 (FGFR2) | in vitro E.coli expression system |
CSB-YP008645CH1 CSB-EP008645CH1 CSB-BP008645CH1 CSB-MP008645CH1 CSB-EP008645CH1-B |
Recombinant Chicken Fibroblast growth factor receptor 2 (FGFR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGFR2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF008645HU | Recombinant Human Fibroblast growth factor receptor 2 (FGFR2) | in vitro E.coli expression system |
CSB-YP008645HU1 CSB-EP008645HU1 CSB-BP008645HU1 CSB-MP008645HU1 CSB-EP008645HU1-B |
Recombinant Human Fibroblast growth factor receptor 2 (FGFR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGFR2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF008645MO | Recombinant Mouse Fibroblast growth factor receptor 2 (Fgfr2) | in vitro E.coli expression system |
CSB-YP008645MO1 CSB-EP008645MO1 CSB-BP008645MO1 CSB-MP008645MO1 CSB-EP008645MO1-B |
Recombinant Mouse Fibroblast growth factor receptor 2 (Fgfr2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |