Name: CEACAM8 (Besilesomab Biosimilar) Recombinant Monoclonal Antibody
Brand: CUSABIO
SKU: CSB-RA005168MB1HU

Product Details

Uniprot No.

P31997

Target Names

CEACAM8

Alternative Names

Carcinoembryonic antigen CGM6 antibody; Carcinoembryonic antigen gene family member 6 antibody; Carcinoembryonic antigen related cell adhesion molecule 8 antibody; Carcinoembryonic antigen-related cell adhesion molecule 8 antibody; CD 66b antibody; CD 67 antibody; CD66b antibody; CD66b antigen antibody; CD67 antibody; CD67 antigen antibody; CEACAM 8 antibody; CEACAM8 antibody; CEAM8_HUMAN antibody; CGM 6 antibody; CGM6 antibody; NCA 95 antibody; NCA95 antibody; Non-specific cross-reacting antigen NCA-95 antibody; Nonspecific cross reacting antigen NCA 95 antibody; Nonspecific cross reacting antigen NCA95 antibody

Species Reactivity

Human

Immunogen

Recombinant Human CEACAM8 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS，pH7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

In stock

Description

This recombinant monoclonal antibody is a research-grade biosimilar to Besilesomab, targeting CEACAM8 (CD66b), a glycosylphosphatidylinositol-anchored glycoprotein of the carcinoembryonic antigen family. CEACAM8 is specifically and abundantly expressed on the surface of human granulocytes, particularly neutrophils, where it plays a role in cell adhesion, activation, and migration during inflammatory responses. This target serves as a reliable marker for granulocyte identification and has been implicated in various inflammatory conditions, infections, and immune-mediated disorders where neutrophil recruitment and activity are critical pathological features.

Besilesomab is a murine IgG1 monoclonal antibody that was developed for imaging inflammatory lesions and infectious foci through its specific binding to granulocyte CEACAM8. This biosimilar provides researchers with a valuable tool for investigating neutrophil biology, studying granulocyte-mediated inflammatory processes, and exploring CEACAM8 function in immune regulation. It enables detailed examination of neutrophil behavior in disease models and facilitates research into inflammatory and infectious disease mechanisms.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Target Background

Function

Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner. Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Heterophilic interaction with CEACAM8 occurs in activated neutrophils.

Gene References into Functions

Increased CD66b positive tumor-infiltrating neutrophils (CD66b + TINs) was significantly associated with presence of metastasis, S stage, and nonseminomatous germ cell tumor diagnosis. PMID: 27863478
Data suggest ways in which carcinoembryonic antigen-related cell adhesion molecules CEACAM6 and CEACAM8 regulate the biological functions of one another. PMID: 26483485
Granulocytes from type 2 diabetes patients display higher granulocyte cell surface expression of CD66b compared with values of healthy controls. PMID: 23686079
The highly elevated gene expression of CEACAM6 and CEACAM8 in primary myelofibrosis can serve as molecular markers of myelofibrotic transformation. PMID: 21470677
All the leukemic samples showed overexpression of CEACAM6 and 8 when compared with normal granulocytes. PMID: 17909799
CD66b molecules are involved in regulating adhesion and activation of eosinophils, possibly through their localization in lipid rafts and interaction with other cell surface molecules, such as CD11b. PMID: 18056392

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Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor. Cell surface.

Protein Families

Immunoglobulin superfamily, CEA family

Tissue Specificity

Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.

Database Links

HGNC: 1820

OMIM: 615747

KEGG: hsa:1088

STRING: 9606.ENSP00000244336

UniGene: Hs.41

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Code	CSB-RA005168MB1HU
Size	US$9799
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CEACAM8 (Besilesomab Biosimilar) Recombinant Monoclonal Antibody

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Target Background