CEACAM8, a key member of the human carcinoembryonic antigen (CEA) family, is a transmembrane glycoprotein with a distinct structural feature. It comprises a transmembrane region and a glycosylated extracellular domain, including a variable N-terminal immunoglobulin (Ig)-like domain and a constant Ig-C2 domain. This structure enables CEACAM8 to specifically interact with other molecules, participating in various biological processes. Functionally, CEACAM8 plays a pivotal role in inflammatory responses and immune regulation, modulating immune reactions by influencing leukocyte adhesion, migration, and intercellular signaling. Although the specific signaling pathways of CEACAM8 remain incompletely understood, it is speculated that it may trigger signaling cascades through interactions with other cell surface receptors or ligands, ultimately influencing cellular behaviors. Additionally, the expression level of CEACAM8 varies under certain disease conditions, highlighting the significance of studying its structure, function, and signaling pathways for understanding disease mechanisms and developing new therapeutics. Through further investigation of CEACAM8, scientists hope to provide novel insights and therapeutic strategies for related diseases.
● Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 8(CEACAM8) (Active)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CEACAM8 at 2μg/mL can bind Anti-CEACAM8 recombinant antibody (CSB-RA005168MA1HU),the EC50 is 19.38-21.68 ng/mL.
● Human Carcinoembryonic antigen-related cell adhesion molecule 8(CEACAM8) ELISA kit
Validated Data
Code:CSB-EL005168HU
Size:96T,5×96T,10×96T
Sensitivity:0.156 ng/mL
Detection Range:0.625 ng/mL-40 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
The following CEACAM8 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CEACAM8 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA005168ESR2HU | CEACAM8 Antibody |
Human | ELISA, IHC |
CSB-PA077200 | CEACAM8 Antibody |
Human | ELISA,IHC |
CSB-RA937940A0HU | CEACAM8 Recombinant Monoclonal Antibody |
Human | ELISA, FC |
CSB-RA005168MA1HU | CEACAM8 Recombinant Monoclonal Antibody |
Human | ELISA |
CEACAM8 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP005168HU CSB-BP005168HU CSB-MP005168HU CSB-EP005168HU-B |
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8) |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP005168HU | Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8) |
E.coli |
CSB-MP005168HU | Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 8(CEACAM8) (Active) |
Mammalian cell |
CEACAM8 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL005168HU | Human Carcinoembryonic antigen-related cell adhesion molecule 8(CEACAM8) ELISA kit |
serum, plasma, tissue homogenates, cell lysates | 0.156 ng/mL |