CEACAM8 Recombinant Monoclonal Antibody

Datasheet

Code	CSB-RA937940A0HU
Size	US$210
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Image	Western Blot Positive WB detected in: HL60 whole cell lysate(30µg), BxPC-3 whole cell lysate(30µg), JK whole cell lysate(30µg), HepG2 whole cell lysate(30µg), HT29 whole cell lysate(30µg),THP-1 whole cell lysate(30µg),Raji whole cell lysate(30µg),A549 whole cell lysate(30µg),Mouse Spleen tissue lysate(20µg) All lanes: CEACAM8 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/40000 dilution Predicted band size: 39, 70-100 kDa Observed band size: 39,100 kDa Exposure time: 120s
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Product Details
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Target Background

Product Details

Uniprot No.

P31997

Target Names

CEACAM8

Alternative Names

Carcinoembryonic antigen-related cell adhesion molecule 8 (CD67 antigen) (Carcinoembryonic antigen CGM6) (Non-specific cross-reacting antigen NCA-95) (CD antigen CD66b), CEACAM8, CGM6

Species Reactivity

Human, Mouse

Immunogen

A synthesized peptide derived from Human CEACAM8

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Isotype

Rabbit IgG

Clone No.

24H12

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The CEACAM8 recombinant monoclonal antibody production process is initiated with in vitro cloning, wherein genes for both the heavy and light chains of the CEACAM8 antibody are integrated into expression vectors. These vectors are subsequently introduced into host cells, enabling the recombinant antibody's expression within a cell culture setting. Following expression, the CEACAM8 recombinant monoclonal antibody is meticulously purified from the supernatant of transfected host cell lines using affinity chromatography. Significantly, this antibody exhibits remarkable specificity in its binding to the human CEACAM8 protein and is highly versatile and suitable for ELISA and FC applications.

CEACAM8 is a cell surface receptor primarily found on neutrophils, and its main function is to facilitate the adhesion, migration, and transendothelial passage of neutrophils during the immune response. CEACAM8 is essential for the recruitment of neutrophils to sites of infection or inflammation, where they play a vital role in defending the body against microbial pathogens and contributing to the inflammatory response.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner. Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Heterophilic interaction with CEACAM8 occurs in activated neutrophils.

Gene References into Functions

Increased CD66b positive tumor-infiltrating neutrophils (CD66b + TINs) was significantly associated with presence of metastasis, S stage, and nonseminomatous germ cell tumor diagnosis. PMID: 27863478
Data suggest ways in which carcinoembryonic antigen-related cell adhesion molecules CEACAM6 and CEACAM8 regulate the biological functions of one another. PMID: 26483485
Granulocytes from type 2 diabetes patients display higher granulocyte cell surface expression of CD66b compared with values of healthy controls. PMID: 23686079
The highly elevated gene expression of CEACAM6 and CEACAM8 in primary myelofibrosis can serve as molecular markers of myelofibrotic transformation. PMID: 21470677
All the leukemic samples showed overexpression of CEACAM6 and 8 when compared with normal granulocytes. PMID: 17909799
CD66b molecules are involved in regulating adhesion and activation of eosinophils, possibly through their localization in lipid rafts and interaction with other cell surface molecules, such as CD11b. PMID: 18056392

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Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor. Cell surface.

Protein Families

Immunoglobulin superfamily, CEA family

Tissue Specificity

Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.

Database Links

HGNC: 1820

OMIM: 615747

KEGG: hsa:1088

STRING: 9606.ENSP00000244336

UniGene: Hs.41

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Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Related pathways

Target Therapy

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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