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KLRK1 (Tesnatilimab Biosimilar) Recombinant Monoclonal Antibody

KLRK1 (Tesnatilimab Biosimilar) Recombinant Monoclonal Antibody

Datasheet

Code	CSB-RA012474MB1HU
Size	US$199
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P26718

Target Names

KLRK1

Alternative Names

ANTI-NKG2D research-grade biosimilar; IPH-2301 research-grade biosimilar; IPH-23XX research-grade biosimilar; JNJ-4500 research-grade biosimilar; JNJ-64304500 research-grade biosimilar; NN-8555 research-grade biosimilar; NNC-0142-0000-0002 research-grade biosimilar; NNC-0142-0002 research-grade biosimilar; NNC-0142-002 research-grade biosimilar; NNC142-0002 research-grade biosimilar; KLRK1 antibody; D12S2489E antibody; NKG2D antibody;NKG2-D type II integral membrane protein antibody; Killer cell lectin-like receptor subfamily K member 1 antibody; NK cell receptor D antibody; NKG2-D-activating NK receptor antibody; CD antigen CD314 antibody

Species Reactivity

Human

Immunogen

Recombinant Human KLRK1 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS,pH7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

3-4 weeks

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Customer Reviews and Q&A

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Target Background

Function

Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.

Subcellular Location

Cell membrane; Single-pass type II membrane protein. Note=Colocalized with HCST on the cell surface.

Tissue Specificity

Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs).

Database Links

HGNC: 18788

OMIM: 611817

KEGG: hsa:100528032

STRING: 9606.ENSP00000240618

UniGene: Hs.387787

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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