KLRK1 Antibody

Datasheet

Code	CSB-PA012474LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA012474LA01HU at dilution of 1:100 Immunofluorescent analysis of A549 cells using CSB-PA012474LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) Western Blot Positive WB detected in: A549 whole cell lysate, HepG2 whole cell lysate All lanes: KLRK1 antibody at 3.7µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 26 kDa Observed band size: 34 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) KLRK1 Polyclonal antibody

Uniprot No.

P26718

Target Names

KLRK1

Alternative Names

KLRK1; D12S2489E; NKG2D; NKG2-D type II integral membrane protein; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor; CD antigen CD314

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human NKG2-D type II integral membrane protein (73-216AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The KLRK1 Antibody (Product code: CSB-PA012474LA01HU) is Non-conjugated. For KLRK1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA012474LB01HU	KLRK1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA012474LC01HU	KLRK1 Antibody, FITC conjugated
Biotin	CSB-PA012474LD01HU	KLRK1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The KLRK1 polyclonal antibody is a type of antibody that recognizes and binds to the human KLRK1 protein. The KLRK1 protein, also known as NKG2D, mainly functions to recognize and binds to stress-induced ligands expressed on the surface of infected or transformed cells, which allows the immune system to detect and eliminate these cells. KLRK1-mediated cytotoxicity is important for the immune response against viral infections and cancer, as well as for the elimination of cells undergoing cellular stress, such as cells undergoing DNA damage or apoptosis.

KLRK1 antibody is derived from multiple clones of B cells within the rabbit immunized with the recombinant human NKG2D protein (73-216aa), which produces a mixture of antibodies that can recognize different epitopes of the KLRK1 protein. The KLRK1 antibody underwent protein G affinity chromatography, getting a purity exceeding 95%. It has been quality validated in ELISA, WB, IHC, and IF applications.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.

Subcellular Location

Cell membrane; Single-pass type II membrane protein. Note=Colocalized with HCST on the cell surface.

Tissue Specificity

Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs).

Database Links

HGNC: 18788

OMIM: 611817

KEGG: hsa:100528032

STRING: 9606.ENSP00000240618

UniGene: Hs.387787

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Related pathways

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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