Name: LILRB2 (Polzastobart Biosimilar) Recombinant Monoclonal Antibody
Brand: CUSABIO
SKU: CSB-RA839793MB7HU

Product Details

Uniprot No.

Q8N423

Target Names

LILRB2

Alternative Names

JTX8064 research-grade biosimilar; JTX-8064 research-grade biosimilar ;LILRB2 antibody; ILT4 antibody; LIR2 antibody; MIR10 antibody; Leukocyte immunoglobulin-like receptor subfamily B member 2 antibody; LIR-2 antibody; Leukocyte immunoglobulin-like receptor 2 antibody; CD85 antigen-like family member D antibody; Immunoglobulin-like transcript 4 antibody; ILT-4 antibody; Monocyte/macrophage immunoglobulin-like receptor 10 antibody; MIR-10 antibody; CD antigen CD85d antibody

Species Reactivity

Human

Immunogen

Recombinant Human LILRB2 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS，pH7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

3-4 weeks

Description

This recombinant monoclonal antibody is designed as a research-grade biosimilar to Polzastobart, targeting LILRB2 (Leukocyte Immunoglobulin-Like Receptor B2), also known as ILT4 or CD85d. LILRB2 is an inhibitory immune checkpoint receptor expressed primarily on myeloid cells, including monocytes, macrophages, and dendritic cells. Upon binding to its ligands, including MHC class I molecules and angiopoietin-like proteins, LILRB2 delivers immunosuppressive signals that dampen immune responses. This receptor plays a critical role in maintaining immune tolerance but is frequently exploited by tumors to create an immunosuppressive microenvironment, making it an important target in cancer immunotherapy research. LILRB2 overexpression has been implicated in various malignancies, including acute myeloid leukemia and solid tumors, where it contributes to immune evasion.

Polzastobart is a therapeutic antibody under clinical investigation for its ability to block LILRB2-mediated immunosuppression and restore anti-tumor immunity. This biosimilar reagent provides researchers with a valuable tool for investigating LILRB2 biology, studying myeloid cell regulation, exploring tumor-immune interactions, and evaluating checkpoint blockade mechanisms in preclinical models.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

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Target Background

Function

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Expressed in monocytes and at lower levels in myeloid and plasmacytoid dendritic cells. Expressed in tolerogenic IL10-producing dendritic cells. Expressed in myeloid-derived suppressor cells during pregnancy. Detected at low levels in natural killer (NK)

Database Links

HGNC: 6606

OMIM: 604815

STRING: 9606.ENSP00000375629

UniGene: Hs.655652

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Code	CSB-RA839793MB7HU
Size	US$9799
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LILRB2 (Polzastobart Biosimilar) Recombinant Monoclonal Antibody

Product Details

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Customer Reviews and Q&A

Target Background