Name: SLAMF7 (Elotuzumab Biosimilar) Recombinant Monoclonal Antibody
Brand: CUSABIO
SKU: CSB-RA021369MB1HU

Product Details

Uniprot No.

Q9NQ25

Target Names

SLAMF7

Alternative Names

BMS-901608 research-grade biosimilar; elotuzumab research-grade biosimilar; Elotuzumab (genetical recombination) (JAN) research-grade biosimilar; Elotuzumab (USAN) research-grade biosimilar; Elotuzumab Genetical Recombination research-grade biosimilar; Empliciti research-grade biosimilar; HuLuc63 research-grade biosimilar; HULUC-63 research-grade biosimilar; Immunoglobulin G1, anti-(human protein CS1) (human-mouse HuLuc63 heavy chain), disulfide with human-mouse HuLuc63 kappa-chain, dimer research-grade biosimilar; PDL063 research-grade biosimilar; PDL-063 research-grade biosimilar ;SLAMF7 antibody; CS1 antibody; UNQ576/PRO1138 antibody; SLAM family member 7 antibody; CD2 subset 1 antibody; CD2-like receptor-activating cytotoxic cells antibody; CRACC antibody; Membrane protein FOAP-12 antibody; Novel Ly9 antibody; Protein 19A antibody; CD antigen CD319 antibody

Species Reactivity

Human

Immunogen

Recombinant Human SLAMF7 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS，pH7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

3-4 weeks

Description

This recombinant monoclonal antibody is designed as a research-grade biosimilar to elotuzumab, targeting SLAMF7 (Signaling Lymphocytic Activation Molecule Family member 7), also known as CS1 or CD319. SLAMF7 is a cell surface glycoprotein predominantly expressed on natural killer cells, activated monocytes, and plasma cells, where it functions as an immune modulator regulating NK cell-mediated cytotoxicity and cellular adhesion. This protein exhibits particularly high expression levels on malignant plasma cells in multiple myeloma, making it a critical biomarker and therapeutic target in hematological malignancies.

Elotuzumab, the reference antibody, is a humanized IgG1 monoclonal antibody approved for multiple myeloma treatment that functions through dual mechanisms: direct activation of NK cells and antibody-dependent cellular cytotoxicity against SLAMF7-expressing tumor cells. This biosimilar antibody provides researchers with a valuable tool for investigating SLAMF7-mediated immune responses, exploring NK cell biology, studying plasma cell disorders, and evaluating immunotherapeutic mechanisms in oncology research. It enables mechanistic studies of SLAMF7 signaling pathways and antibody-based immunotherapy approaches.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

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Target Background

Function

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells. May play a role in lymphocyte adhesion. In LPS-activated monocytes negatively regulates production of proinflammatory cytokines.; Isoform 3 does not mediate any NK cell activation.

Gene References into Functions

Memory CD8+ T cells from SLE patients displayed decreased amounts of SLAMF7, a surface receptor that characterizes effector CD8+ T cells. Ligation of SLAMF7 increased CD8+ T cell degranulation capacity and the percentage of IFNgamma-producing cells in response to antigen challenge in SLE patients and healthy controls. SLAMF7 engagement promoted cytotoxic lysis of target cells in response to stimulation with viral antig... PMID: 28076903
phagocytosis of haematopoietic tumour cells during SIRPalpha-CD47 blockade was strictly dependent on SLAM family receptors in vitro and in vivo; in both mouse and human cells, this function required a single SLAM family member, SLAMF7 (also known as CRACC, CS1, CD319), expressed on macrophages and tumour cell targets PMID: 28424516
Cohort statistics revealed a significant increase of circulating sSLAMF7 in multiple myeloma patients versus normal controls PMID: 27116021
Blimp-1 regulates the transcription of CS1 gene in NK and B cell lines from multiple myeloma and diffuse large B cell lymphoma patients. PMID: 26310579
SLAMF7-triggered inhibition is mediated by a mechanism involving Src kinases, CD45, and SHIP-1 that is defective in MM cells PMID: 25312647
Our data highlight the therapeutic potential of targeting CD319 in rheumatoid arthritis PMID: 24299175
SLAMF7 plays an inhibitory role in human monocytes to control proinflammatory immune responses. PMID: 23695528
These results suggest a role for CD319 and CD229 in the systemic lupus erythematosus disease process. PMID: 23956418
These data suggest an involvement of CRACC-mediated NK cell activation in periodontal tissue destruction and point to a plausible distinction in the pathobiology of aggressive and chronic periodontitis. PMID: 23250953
CS1-L and CS1-S may differentially regulate human NK cell functions PMID: 15368295
CS1 may play a role in the regulation of B lymphocyte proliferation during immune responses PMID: 17878365
CS1 was expressed at adhesion-promoting uropod membranes of polarized Multiple Myeloma cells, andis required for MM cell adhesion to bone marrow stromal cells PMID: 17906076
HuLuc63 eliminates myeloma cells, at least in part, via NK-mediated ADCC and shows the therapeutic potential of targeting CS1 with HuLuc63 for the treatment of multiple myeloma. PMID: 18451245

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Tissue Specificity

Expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. Expressed

Database Links

HGNC: 21394

OMIM: 606625

KEGG: hsa:57823

STRING: 9606.ENSP00000357022

UniGene: Hs.517265

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Code	CSB-RA021369MB1HU
Size	US$9799
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SLAMF7 (Elotuzumab Biosimilar) Recombinant Monoclonal Antibody

Product Details

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Customer Reviews and Q&A

Target Background