DXD Monoclonal Antibody - Highly Potent Tool for ADCs Pharmacokinetic (PK) Analysis!

DXD Monoclonal Antibody - Highly Potent Tool for ADCs Pharmacokinetic (PK) Analysis!

Exatecan derivative for ADC (DXD) is an inhibitor targeting DNA topoisomerase I, belonging to the camptothecin (CPT) class of compounds. DNA topoisomerase I inhibitors currently stand as the most promising ADC payloads, causing DNA damage and cell apoptosis by cleaving single-strand DNA and suppressing the topoisomerase repair mechanism. The new generation DXD-ADC employs DXD as a drug carrier (payload) that effectively determines DXD stability and release efficiency, applicable in plasma/serum pharmacokinetic analysis of ADC drugs, determination of drug binding affinity, analysis of Drug Antibody Ratio (DAR), and evaluation of ADC drug efficacy.

DXD-the most promising payload for next-generation ADCs

Figure. 1 DXD-the most promising payload for next-generation ADCs [1]

Application Scenarios

This tool serves as a core instrument for conducting PK (Pharmacokinetic) analysis of DXD-ADCs and qualitative analysis of coupled DAR values, expediting the R&D process of ADC drugs.

Desirable Characteristics of DXD-ADC

  • a highly potent payload (DXD) with a short systemic half-life;
  • a cleavable linker designed to be tumor selective which is stable in circulation;
  • an average drug-to-antibody ratio (DAR) up to 8 being optimized for each target;
  • DXD with more potent inhibitory activity of Topo I than SN-38.

CUSABIO DXD Monoclonal Antibodies

Product Advantages

High Purity

Purity validated to be over 90% through SDS-PAGE.

High Sensitivity

Anti-DXD antibody activity verified through binding with leading ADC drug DS-8201.

Expert Technical Team

Responsive within 24 hours for any pre-sales or after-sales inquiries.

Code Product Name Application
CSB-MA996977I1m DXD Monoclonal Antibody ELISA
CSB-MA996977I1m-B DXD Monoclonal Antibody, HRP conjugated ELISA
CSB-MA996977I2m DXD Monoclonal Antibody ELISA
CSB-MA996977I2m-B DXD Monoclonal Antibody, HRP conjugated ELISA

More: Anti-Payload Antibody DXD: a Highly Potent Tool for ADCs Pharmacokinetic (PK) Analysis!

References

[1] https://xueqiu.com/8965749698/192610616

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