Immune Checkpoints

Immune checkpoints are regulators of immune activation by regulating the antigen recognition of T cell receptor (TCR) in the process of immune response. They play a key role in maintaining immune homeostasis and preventing autoimmunity.

Based on the different role for immune activation, immune checkpoints are divided into two types: co-stimulatory immune checkpoints and co-inhibitory immune checkpoints.

Co-stimulatory immune checkpoints refer to one kind of immune checkpoint which can stimulate immune progress, such as CD28, ICOS, and CD137.

On the contract, co-inhibitory immune checkpoints play a negative role to immune progress. They inhibit immune progress, such as PD1, CTLA-4, and VISTA.

In cancer, immune checkpoint mechanisms are often activated to suppress the nascent anti-tumor immune response. This has led to the development of several checkpoint inhibitor antibody drugs that are currently being tested in clinical trials or have been approved for a number of cancers.

PD-L1(CD274) or PD-L2(CD273) CD80 or CD86 ICOSL(CD275) CD276 / VICN1 VISTA HHLA2 Butyrophilin Family Members (e.g. Btnl2 , Skint1, MOG , CD277 ) HVEM(CD270) MHC class I or II TNFSF9(CD137L) OX40L(CD252) TNFSF7(CD70) TNFRSF5(CD40) GIRL(TNFSF18) PVR(CD155) NECTIN-2(CD112) MOX1(CD200) BCM-1(CD48) Gal-9 Adenosine IDO1 ; TDO ? PD-1(CD279) CD28(TP44) CTLA-4(CD152) ICOS(CD278) ? ? TMIGD2(CD28H) ? ? BTLA(CD272) KIR_S KIR_L TCR LAG-3(CD223) TNFRSF-9(CD137) OX40(CD134) TNFRSF7(CD27) CD40L(CD154) GITR(CD357) CD96 DNAM-1(CD226) TIGIT CD112R CD200R 2B4(CD244) TIM-3(CD366) A2aR Tryptophan

The Products of Immune Checkpoints

Recently, the R&D team from CUSABIO has developed various recombinant proteins of immune checkpoints for the researchers in this filed.

These recombinant immune checkpoint proteins cover multiple species and labels, and their biological activities are strictly analyzed and verified before shipping. In addition, we provide protein customization service. If you can't find the protein you need, please contact us for custom service.

Gene Name	Uniprot ID	Code	Product Name	Source
CD19	P15391	CSB-AP005061HU	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active)	Mammalian cell
CTLA4	H0VUB1	CSB-AP005121GU	Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active)	Yeast
TNFRSF9	Q07011	CSB-AP005131HU	Recombinant Human Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), partial (Active)	Mammalian cell
TNFRSF9	Q07011	CSB-AP005141HU	Recombinant Human Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), partial (Active)	Mammalian cell
TNFRSF9	Q07011	CSB-AP005151HU	Recombinant Human Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), partial (Active)	Mammalian cell
CD86	AAH40261.1	CSB-AP005161HU	Recombinant Human T-lymphocyte activation antigen CD86 (CD86), partial (Active)	Mammalian cell
CD40	P25942	CSB-AP005171HU	Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)^Unavailable	Mammalian cell
CD40	P25942	CSB-AP005181HU	Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	Mammalian cell
CD40LG	P29965	CSB-AP005191HU	Recombinant Human CD40 ligand (CD40LG), partial (Active)	E.coli
CD47	Q08722	CSB-AP005201HU	Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	Mammalian cell
CD47	Q08722	CSB-AP005211HU	Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)^Unavailable	Mammalian cell
CD160	O95971	CSB-AP005221HU	Recombinant Human CD160 antigen (CD160) (Active)^Unavailable	Mammalian cell
CTLA4	P16410	CSB-AP005231HU	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)^Unavailable	Mammalian cell
TNFRSF4	P43489	CSB-AP005241HU	Recombinant Human Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), partial (Active)	Mammalian cell
TNFRSF4	P43489	CSB-AP005251HU	Recombinant Human Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), partial (Active)	Mammalian cell
TNFSF4	P23510	CSB-AP005261HU	Recombinant Human Tumor necrosis factor ligand superfamily member 4 (TNFSF4), partial (Active)^Unavailable	Mammalian cell
SIRPA	CAA71403.1	CSB-AP005271HU	Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA), partial (Active)	Mammalian cell
HAVCR2	AAL65157.1	CSB-AP005281HU	Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active)^Unavailable	Mammalian cell
HAVCR2	AAL65157.1	CSB-AP005291HU	Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active)^Unavailable	Mammalian cell
Ctla4	P09793	CSB-AP005301MO	Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active)	Mammalian cell
Tnfrsf14	Q80WM9	CSB-AP005311MO	Recombinant Mouse Tumor necrosis factor receptor superfamily member 14 (Tnfrsf14), partial (Active)	Mammalian cell
Tnfrsf4	P47741	CSB-AP005321MO	Recombinant Mouse Tumor necrosis factor receptor superfamily member 4 (Tnfrsf4), partial (Active)^Unavailable	Mammalian cell
Tnfrsf4	P47741	CSB-AP005331MO	Recombinant Mouse Tumor necrosis factor receptor superfamily member 4 (Tnfrsf4), partial (Active)^Unavailable	Mammalian cell
Havcr2	Q8VIM0	CSB-AP005341MO	Recombinant Mouse Hepatitis A virus cellular receptor 2 homolog (Havcr2), partial (Active)^Unavailable	Mammalian cell
Cd47	Q61735	CSB-AP005351MO	Recombinant Mouse Leukocyte surface antigen CD47 (Cd47), partial (Active)^Unavailable	Mammalian cell
EGFR	P00533	CSB-MP007479HU	Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active)	Mammalian cell
TNFRSF17	Q02223	CSB-MP023974HU1	Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), partial (Active)	Mammalian cell
TACSTD2	P09758	CSB-MP023072HU1	Recombinant Human Tumor-associated calcium signal transducer 2 (TACSTD2), partial (Active)	Mammalian cell
MSLN	Q13421	CSB-MP015044HUc9	Recombinant Human Mesothelin (MSLN), partial (Active)	Mammalian cell
CD44	P16070	CSB-MP004938HU(F1)	Recombinant Human CD44 antigen (CD44), partial (Active)	Mammalian cell
EPHA3	P29320	CSB-MP007723HU	Recombinant Human Ephrin type-A receptor 3 (EPHA3), partial (Active)	Mammalian cell
CD274	Q9NZQ7	CSB-MP878942HU1	Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	Mammalian cell
KLRK1	P26718	CSB-MP012474HU1	Recombinant Human NKG2-D type II integral membrane protein (KLRK1), partial (Active)	Mammalian cell
CD22	P20273	CSB-MP004900HU	Recombinant Human B-cell receptor CD22 (CD22), partial (Active)	Mammalian cell
CD276	Q5ZPR3	CSB-MP733578HU	Recombinant Human CD276 antigen (CD276), partial (Active)	Mammalian cell

More Important Information of Immune Checkpoints

What are Immune Checkpoints ?

What are Immune Checkpoint Proteins?

What is An Immune Checkpoint Inhibitor?

What is Immune Checkpoint Therapy?

What Are Immune Checkpoint Pathways?