ABR Antibody

Code CSB-PA622521LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: Mouse brain tissue
    All lanes: ABR antibody at 3.4μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 98, 94, 36, 93 kDa
    Observed band size: 98 kDa

  • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA622521LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ABR Polyclonal antibody
Uniprot No.
Target Names
ABR
Alternative Names
abr antibody; ABR_HUMAN antibody; Active BCR related antibody; Active BCR related gene antibody; Active breakpoint cluster region related protein antibody; Active breakpoint cluster region-related protein antibody; MDB antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Active breakpoint cluster region-related protein (797-859AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ABR Antibody (Product code: CSB-PA622521LA01HU) is Non-conjugated. For ABR Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA622521LB01HU ABR Antibody, HRP conjugated ELISA
FITC CSB-PA622521LC01HU ABR Antibody, FITC conjugated
Biotin CSB-PA622521LD01HU ABR Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. Functions as an important negative regulator of neuronal RAC1 activity. Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity.
Gene References into Functions
  1. ABR depletion leads to G2/M accumulation in human embryonic stem cells. Centrosome dynamics and mitotic fidelity are compromised upon ABR depletion. When mitosis progresses without ABR, human embryonic stem cells show a high incidence of aneuploidy. PMID: 28579391
  2. During vestibular morphogenesis, Abr and Bcr play complementary roles. Small Rho-related GTPases like Abr and Bcr are important for balance and motor coordination. PMID: 11921339
Subcellular Location
Cell projection, dendritic spine. Cell projection, axon. Cell junction, synapse.
Tissue Specificity
Highly enriched in the brain. Much weaker expression in heart, lung and muscle.
Database Links

HGNC: 81

OMIM: 600365

KEGG: hsa:29

STRING: 9606.ENSP00000303909

UniGene: Hs.159306

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