ACTR8 Antibody

Code CSB-PA872523LA01HU
Size US$166
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  • Western blot
    All lanes: ACTR8 antibody at 16µg/ml
    Lane 1: A549 whole cell lysate
    Lane 2: HCT116 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 71, 59, 37 kDa
    Observed band size: 71 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ACTR8 Polyclonal antibody
Uniprot No.
Target Names
ACTR8
Alternative Names
Actin-related protein 8 antibody; Actr8 antibody; ARP8_HUMAN antibody; hArp8 antibody; INO80 complex subunit N antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Actin-related protein 8 protein (35-175AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ACTR8 Antibody (Product code: CSB-PA872523LA01HU) is Non-conjugated. For ACTR8 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA872523LB01HU ACTR8 Antibody, HRP conjugated ELISA
FITC CSB-PA872523LC01HU ACTR8 Antibody, FITC conjugated
Biotin CSB-PA872523LD01HU ACTR8 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex.
Gene References into Functions
  1. Plays a regulatory role in the binding of Arp8 to DNA. PMID: 25299602
  2. Binding studies reveal that Arp8 and the Arp8-Arp4-actin-HSA sub-complex of INO80 strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting that Arp8 functions as a nucleosome recognition module. PMID: 22977180
  3. These results suggest that ARP8 is required for the recruitment of the mammalian INO80 complex to the laser-induced DNA damage sites. PMID: 20971067
  4. Expression of truncated hArp8 proteins and depletion of endogenous hArp8 by RNA interference caused misalignment of mitotic chromosomes, suggesting that chromosome-associated hArp8 has a role in chromosome behavior. PMID: 18163988
Subcellular Location
Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes.
Protein Families
Actin family, ARP8 subfamily
Database Links

HGNC: 14672

KEGG: hsa:93973

STRING: 9606.ENSP00000336842

UniGene: Hs.412186

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