ACYP2 Antibody

Code CSB-PA001266LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA001266LA01HU at dilution of 1:100

  • Immunofluorescent analysis of U251 cells using CSB-PA001266LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ACYP2 Polyclonal antibody
Uniprot No.
Target Names
ACYP2
Alternative Names
Acylphosphatase 2 antibody; Acylphosphatase 2 muscle type antibody; Acylphosphatase antibody; Acylphosphatase muscle type isozyme antibody; Acylphosphatase-2 antibody; Acylphosphatase2 antibody; Acylphosphate phosphohydrolase 2 antibody; Acylphosphate phosphohydrolase antibody; ACYM antibody; ACYP 2 antibody; ACYP antibody; Acyp2 antibody; ACYP2_HUMAN antibody; Muscle type acylphosphatase 2 antibody; muscle type isozyme antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Acylphosphatase-2 protein (28-87AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ACYP2 Antibody (Product code: CSB-PA001266LA01HU) is Non-conjugated. For ACYP2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA001266LB01HU ACYP2 Antibody, HRP conjugated ELISA
FITC CSB-PA001266LC01HU ACYP2 Antibody, FITC conjugated
Biotin CSB-PA001266LD01HU ACYP2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Its physiological role is not yet clear.
Gene References into Functions
  1. the genetic polymorphisms of ACYP2 and TSPYL6 are associated with increased risk of developing ischemic stroke PMID: 27686078
  2. Results found an association between the ACYP2 rs1872328 polymorphism and cisplatin-induced ototoxicity. PMID: 28445188
  3. Our results indicate that ACYP2 polymorphisms may influence the GC risk and may serve as a new precursory biomarker in the northwest Chinese Han population. PMID: 28415712
  4. Findings indicate significant associations between single nucleotide oolymorphism (SNPs) in the acylphosphatase 2 (ACYP2) gene and breast cancer (BC) risk in a Han Chinese population. PMID: 27894080
  5. ACYP2 gene may be associated with an increased risk of esophageal carcinoma in Chinese Han populations. Future studies to address the biological function of this polymorphism in the development of esophageal carcinoma are warranted. PMID: 28424424
  6. three SNPs in ACYP2 (rs1682111, rs11896604 and rs843720) associate with lung cancer in the Chinese Han population. PMID: 27974682
  7. Genetic polymorphisms in the telomere length-related gene ACYP2 are associated with the risk of colorectal cancer in a Chinese Han population. PMID: 28039478
  8. Data show that the acylphosphatase 2 (ACYP2) gene polymorphism significantly decreased the risk of high altitude pulmonary edema (HAPE). PMID: 27552709
  9. Rs6713088, rs843752, and rs17045754 associated with high-altitude pulmonary edema risk PMID: 28353602
  10. Results shown that the previously reported association of an ACYP2 variant with cisplatin-induced hearing loss in pediatric brain tumor patients could be replicated in an independent cohort of patients with osteosarcoma. Therefor, the ACYP2 variant should be considered a predictor of cisplatin-induced hearing loss in patients with osteosarcoma or other solid tumors PMID: 26928270
  11. These findings suggest a minor role of the single nucleotide polymorphisms of ACYP2 investigated as genetic determinants of chronic oxaliplatin-induced peripheral neurotoxicity. PMID: 25858589
  12. The ACYP2 risk variant strongly predisposed these patients to precipitous hearing loss and was related to ototoxicity severity. PMID: 25665007
  13. Enhanced stability is observed upon modifications of a loop region in the enzyme acylphosphatase and is achieved despite significant enthalpy losses. PMID: 23754389
  14. The study used a stopped-flow device coupled to turbidometry detection to monitor the rapid conversion of human muscle acylphosphatase into oligomers with varying heparan sulfate and protein concentrations. PMID: 22522822
  15. Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding. PMID: 10542090
  16. effects of 40 single point mutations on the conversion of the denatured form of the alpha/beta protein acylphosphatase (AcP) into insoluble aggregates PMID: 11799398
  17. studies of aggregates formed from human muscle acylphosphatase and disaggregation suggests that amyloid formation occurs in discrete steps whose reversibility is increasingly difficult, and dependent on the size of the aggregates PMID: 15670608
  18. Most of the conserved glycine residues in this protein could have been maintained during evolution because of their ability to inhibit amyloid aggregation. PMID: 16084386
  19. extensive mutational analysis of aggregation and disaggregation of amyloid-like protofibrils of muscle acylphosphatase PMID: 18809411

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Protein Families
Acylphosphatase family
Database Links

HGNC: 180

OMIM: 102595

KEGG: hsa:98

STRING: 9606.ENSP00000378161

UniGene: Hs.516173

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