ARPIN Antibody

Code CSB-PA773801LA01HU
Size US$166
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  • Western blot
    All lanes: ARPIN antibody at 0.5µg/ml + HepG2 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 25, 44 kDa
    Observed band size: 25 kDa

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA773801LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA773801LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ARPIN Polyclonal antibody
Uniprot No.
Target Names
ARPIN
Alternative Names
2610034B18Rik antibody; Actin related protein 2/3 complex inhibitor antibody; Arp2/3 inhibition protein antibody; ARPIN antibody; C15orf38 antibody; Chromosome 15 open reading frame 38 antibody; CO038_HUMAN antibody; Hypothetical protein LOC348110 antibody; MGC61550 antibody; RIKEN cDNA 2610034B18 antibody; UPF0552 protein C15orf38 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Arpin protein (1-226AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ARPIN Antibody (Product code: CSB-PA773801LA01HU) is Non-conjugated. For ARPIN Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA773801LB01HU ARPIN Antibody, HRP conjugated ELISA
FITC CSB-PA773801LC01HU ARPIN Antibody, FITC conjugated
Biotin CSB-PA773801LD01HU ARPIN Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.
Gene References into Functions
  1. ARPIN is down-regulated in breast cancer cells and predicts poor prognosis in breast cancer patients. Data suggest that restoration of ARPIN in breast cancer cells suppresses cell proliferation, colony formation, cell cycle distribution, invasion in vitro, and tumorigenesis in vivo (xenograft experiments in nude mice); Arpin acts as tumor suppressor in breast cancer and is associated with inhibition of Akt signaling. PMID: 28531800
  2. Low Arpin levels are associated with clinicopathological variables and a poor prognosis in gastric cancer patients PMID: 28293092
  3. Data reveal that Arpin is comprised of an elongated globular core from which the C-terminal tail extends as a linear peptide, thus forming a primary epitope that is readily available to tether Arpin to interacting proteins. PMID: 26774128
  4. Arpin downregulation may contribute to the initiation and development of breast cancer metastasis. PMID: 26648569
  5. Arpin protein affects the expression of tight junction proteins and may have an impact on bacterial translocation in severe acute pancreatitis. PMID: 25892881

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Subcellular Location
Cell projection, lamellipodium.
Protein Families
Arpin family
Database Links

HGNC: 28782

OMIM: 615543

KEGG: hsa:348110

STRING: 9606.ENSP00000350075

UniGene: Hs.6734

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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