ATAD5 Antibody

1. Report rare ATAD5 missense mutations may contribute to genetic susceptibility breast cancer and epithelial ovarian carcinoma. PMID: 27045477
2. Authors discuss many functions of Elg1 protein as embryonic lethal when lost in mice, as a tumor suppressor in mice and humans, interacts with human Fanconi Anemia pathway and may contribute to some of the phenotypes associated with neurofibromatosis. [Review] PMID: 25795125
3. Elg1 has an important role in maintaining chromosome integrity by regulating PCNA levels on chromatin, thereby acting as a PCNA unloading factor. PMID: 23937667
4. ATAD5 regulates the cycle of DNA replication factories, probably through its PCNA-unloading activity. PMID: 23277426
5. loss-of-function mutations in mammalian Atad5 are sufficient to cause genomic instability and tumorigenesis. PMID: 21901109
6. Studies indicate that USP1 and ELG1 as regulators of PCNA ubiquitylation. PMID: 21640107
7. Human ELG1 protein is stabilized and localized to form foci at sites of stalled DNA replications that are different from DNA double strand breaks foci. PMID: 19755857
8. The Frag1 signal pathway, by linking replication stress surveillance with apoptosis induction, plays a central role in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. PMID: 15983387

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HGNC: 25752

OMIM: 609534

KEGG: hsa:79915

STRING: 9606.ENSP00000313171

UniGene: Hs.528902