ATG4B Antibody

Code CSB-PA002290GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
ATG4B
Alternative Names
APG4 autophagy 4 homolog B antibody; APG4B antibody; ATG4 autophagy related 4 homolog B (S. cerevisiae) antibody; ATG4B antibody; ATG4B_HUMAN antibody; AUT like 1 cysteine endopeptidase antibody; AUT-like 1 cysteine endopeptidase antibody; AUTL1 antibody; Autophagin 1 antibody; Autophagin-1 antibody; Autophagy related 4B cysteine peptidase antibody; Autophagy related cysteine endopeptidase 1 antibody; Autophagy related protein 4 homolog B antibody; Autophagy-related cysteine endopeptidase 1 antibody; Autophagy-related protein 4 homolog B antibody; Cysteine protease ATG4B antibody; hAPG4B antibody; MGC1353 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human ATG4B
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Gene References into Functions
  1. ATG4B expression was observed markedly upregulated by EWS-FLI1 overexpression, and silencing of ATG4B dramatically inhibits autophagy in Ewing sarcoma cells. PMID: 28902354
  2. study demonstrates that Rab7b regulates LC3 processing by modulating Atg4B activity; taken together, findings reveal Rab7b as a novel negative regulator of autophagy through its interaction with Atg4B PMID: 28835545
  3. ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8 PMID: 28287329
  4. O-GlcNAcylation of ATG4B regulates autophagy activation by increasing its proteolytic activity under metabolic stress condition PMID: 27527864
  5. these results demonstrate a novel association of ATG4B positive expression with HER2 positive breast cancers PMID: 27556700
  6. Knockdown of ATG4B had only a minor effect on AMPK activation and G1 phase arrest in liver kinase B1-deficient or AMPK-inhibited cancer cells. PMID: 29169176
  7. Our work describes an MST4-ATG4B signaling axis that influences glioblastoma autophagy and malignancy PMID: 29232556
  8. Data show that ULK1, a protein kinase activated at the autophagosome formation site, phosphorylates human ATG4B on serine 316. PMID: 28821708
  9. Reporter assay showed that HSF1 increased the transcriptional activity of ATG4B gene promoter, and chromatin immunoprecipitation assay verified that HSF1 bound to the site (-1429 to -1417) in ATG4B gene promoter region. PMID: 28889000
  10. The structure and regulatory machinery of Atg4b [review] PMID: 28253956
  11. MIRlet-7i is able to regulate autophagic activity via regulating Atg4B expression, which might contribute to the pathogenesis of pre-eclampsia. PMID: 27770612
  12. Results demonstrated that upregulation of miR-34a by transfection or demethylation resulted in the enhanced apoptosis and drug sensitivity in prostate cancer cells. ATG4B, directly regulated by miR-34a through AMPK/mTOR, was involved in this process. PMID: 26499184
  13. Purified ATG4B protein interact with LC3B in vitro. PMID: 25652856
  14. ATG4B independently plays a role as a positive regulator on tumor proliferation and a negative regulator on autophagy in colorectal cancer cells. PMID: 24991826
  15. This study identifies ATG4B as a potential biomarker for predicting therapeutic response in treatment-naive chronic myeloid leukemia stem/progenitor cells and uncovers ATG4B as a possible drug target in these cells. PMID: 24755409
  16. The actions of ATG4 family members (particularly ATG4B) are required for the control of autophagosome fusion with late, degradative compartments in differentiating human erythroblasts. PMID: 23508006
  17. HsAtg4B negatively regulates the localization of LC3 to a membrane compartment by delipidation PMID: 15187094
  18. analysis of specificity and catalysis of HsAtg4B PMID: 16183633
  19. crystal structure of human Atg4b by X-ray crystallography at 2.0 A resolution, and show that Atg4b is a cysteine protease whose active catalytic triad site consists of Cys74, His280 and Asp278 PMID: 16325851
  20. Murine Atg8L/Apg8L modification is mediated by human Atg4B. PMID: 16704426
  21. The crystal structures of catalytically inert human Atg4B in complex with processed and unprocessed forms of LC3 showed that, on LC3 binding, the regulatory loop and the N-terminal tail of HsAtg4B undergo large conformational changes. PMID: 19322194

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Subcellular Location
Cytoplasm.
Protein Families
Peptidase C54 family
Database Links

HGNC: 20790

OMIM: 611338

KEGG: hsa:23192

STRING: 9606.ENSP00000384259

UniGene: Hs.283610

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