BAG5 Antibody

Code CSB-PA890743ESR1HU
Size US$166
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Image
  • Western blot
    All lanes: BAG5 antibody at 1µg/ml + A549 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 52, 57 kDa
    Observed band size: 52 kDa

  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA890743ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA890743ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA890743ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) BAG5 Polyclonal antibody
Uniprot No.
Target Names
BAG5
Alternative Names
BAG family molecular chaperone regulator 5 antibody; BAG-5 antibody; BAG5 antibody; BAG5_HUMAN antibody; Bcl 2 associated athanogene 5 antibody; Bcl-2-associated athanogene 5 antibody; BCL2 associated athanogene 5 antibody; KIAA0873 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human BAG family molecular chaperone regulator 5 protein (198-447AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN. May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.
Gene References into Functions
  1. BAG5 was found as a expression variability marker in an 8-cell human embryo. PMID: 26288249
  2. Subsequent BAG5 upregulation ameliorated the tumor-suppressive effects of miR-127-3p overexpression in epithelial ovarian cancer (EOC). In conclusion, miR-127-3p functions as a tumor suppressor in EOC, and its influence on EOC is directly through regulation of BAG5. PMID: 27571744
  3. High BAG5 expression is associated with pancreatic cancer. PMID: 27571739
  4. This study showed that BAG2 (Bcl-2 associated athanogene family protein 2) and BAG5 (Bcl-2-associated athanogene family protein 5) stabilise pathogenic ataxin3-80Q by inhibiting its ubiquitination. PMID: 25006867
  5. BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation. PMID: 24475098
  6. BAG5 is a binding partners of LRRK2 and part of a complex that promotes clearance of Golgi-derived vesicles through the autophagy-lysosome system. PMID: 24510904
  7. Bag5 is overexpressed in prostate cancer and plays a role in endoplamic reticulum-stress induced apoptosis. Furthermore we have identified GRP78/BiP as a novel interaction partner of Bag5. PMID: 23448667
  8. BAG5 directly interacts with Parkin and stabilizes Parkin via the ubiquitin-mediated proteasomal pathway. PMID: 21131737
  9. A novel function for BAG5 as a modulator of CHIP E3 ubiquitin ligase activity with implications for CHIP-mediated regulation of alpha-syn oligomerization. PMID: 21358815
  10. We replicated the association of BCL2L11 and CASP9 with non-Hodgkin's lymphoma risk at the gene and SNP level, and identified novel associations with BCLAF1 and BAG5. PMID: 20855536
  11. Bcl-2-associated athanogene 5 (BAG5) is a negative regulator of both Hsp70 and parkin function that sensitizes dopaminergic neurons to injury-induced death. PMID: 15603737

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Database Links

HGNC: 941

OMIM: 603885

KEGG: hsa:9529

STRING: 9606.ENSP00000338814

UniGene: Hs.5443

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