BAZ1A Antibody

Datasheet

Code	CSB-PA140877
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA140877(BAZ1A Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details
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Target Background

Product Details

Uniprot No.

Q9NRL2

Target Names

BAZ1A

Alternative Names

Acf1 antibody; ACF1; drosophila; homolog of antibody; ATP dependent chromatin remodelling protein antibody; ATP utilizing chromatin assembly and remodeling factor 1 antibody; ATP-dependent chromatin-remodeling protein antibody; ATP-utilizing chromatin assembly and remodeling factor 1 antibody; B930060C03 antibody; Baz1a antibody; BAZ1A_HUMAN antibody; BC065123 antibody; Bromodomain adjacent to zinc finger domain 1A antibody; Bromodomain adjacent to zinc finger domain protein 1A antibody; cbp146 antibody; CHRAC subunit ACF1 antibody; DKFZp586E0518 antibody; FLJ14383 antibody; Gtl5 antibody; hACF1 antibody; hWALp1 antibody; WALp1 antibody; WCRF180 antibody; Williams syndrome transcription factor related chromatin remodeling factor 180 antibody; Williams syndrome transcription factor-related chromatin-remodeling factor 180 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human BAZ1A

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:2000
IHC	1:25-1:100

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner. The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex. Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex. Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase. May have a role in nuclear receptor-mediated transcription repression.

Gene References into Functions

Results from the study on gene variability in early stage embryos identifies BAZ1A as a putative variability marker of the 8-cell embryo stage. PMID: 26288249
Results from the study suggest that acute cocaine exposure increased Baz1a expression in nucleus accumbens while repeated cocaine exposure produced the opposite effect. Findings implicate BAZ1A in molecular and behavioral plasticity to cocaine and offer new insight into the pathophysiology of cocaine addiction. PMID: 28412501
promotes recovery after DNA damage, in part by recruiting SMARCA5 to damaged chromatin PMID: 29021563
Study reports de novo mutation in BAZ1A, in a patient with a syndromic form of intellectual disability (ID). This mutation affects the expression of genes involved in several biological pathways such as vitamin D regulation, Wnt signaling, and postsynaptic signaling. Data point to an important role for BAZ1A in neurodevelopment, and highlight a possible link for BAZ1A to ID. PMID: 27328812
CHD3.1 and ACF1-SNF2H display counteractive activities but similar histone affinities. PMID: 25533843
ISWI proteins Snf2H, Snf2L as well as Acf1 accumulate at UV-induced DNA damage sites within tens of seconds and reach a plateau after a few minutes. PMID: 21738833
hACF1-containing factors are more generally involved in the DNA damage response. PMID: 21745822
The ACF1 and its complexes play important roles in DNA double-strand breaks (DSBs) repair. PMID: 21172662
The data support a model in which the human ACF anf yeast RSC remodeling enzymes move nucleosomes to new locations by a general sequence-independent mechanism. PMID: 19450608
ACF1 alters the remodeling strategy of SNF2h PMID: 16877760
Has a critical role in the transcriptional repression of specific nuclear hormone receptor-regulated genes. PMID: 17519354

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Subcellular Location

Nucleus. Note=May target the CHRAC complex to heterochromatin.

Protein Families

WAL family

Tissue Specificity

Highly expressed in testis and at low or undetectable levels in other tissues analyzed.

Database Links

HGNC: 960

OMIM: 605680

KEGG: hsa:11177

STRING: 9606.ENSP00000353458

UniGene: Hs.509140

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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