BCAN Antibody

Code CSB-PA002590GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
BCAN
Alternative Names
BCAN antibody; BEHAB antibody; CSPG7 antibody; UNQ2525/PRO6018 antibody; Brevican core protein antibody; Brain-enriched hyaluronan-binding protein antibody; BEHAB antibody; Chondroitin sulfate proteoglycan 7 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human BCAN
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.
Gene References into Functions
  1. Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis. PMID: 22930747
  2. High Brevican is associated with the invasive phenotype of low-grade astrocytoma. PMID: 21997179
  3. Authors describe the expression of BEHAB/brevican in human brain and characterize two novel glioma-specific isoforms which are generated by differential glycosylation and are absent from normal adult brain and other neuropathologies. PMID: 16061654
  4. These results demonstrate for the first time that ADAMTS-5 is capable of degrading brevican and is overexpressed in glioblastoma cells, and suggest that ADAMTS-5 may play a role in glioma cell invasion through the cleavage of brevican. PMID: 16133547
  5. The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility PMID: 18611854

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Subcellular Location
[Isoform 1]: Secreted, extracellular space, extracellular matrix.; [Isoform 2]: Membrane; Lipid-anchor, GPI-anchor.
Protein Families
Aggrecan/versican proteoglycan family
Tissue Specificity
Expressed in the retina, specifically in the inner nuclear layer, inner plexiform layer and ganglion cell layer (at protein level).
Database Links

HGNC: 23059

OMIM: 600347

KEGG: hsa:63827

STRING: 9606.ENSP00000331210

UniGene: Hs.516904

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