BEX2 Antibody

Code CSB-PA883628LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA883628LA01HU at dilution of 1:100

  • Immunofluorescence staining of HepG2 cells with CSB-PA883628LA01HU at 1:333, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) BEX2 Polyclonal antibody
Uniprot No.
Target Names
BEX2
Alternative Names
BEX2Protein BEX2 antibody; Brain-expressed X-linked protein 2 antibody; hBex2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein BEX2 protein (1-128AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The BEX2 Antibody (Product code: CSB-PA883628LA01HU) is Non-conjugated. For BEX2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA883628LB01HU BEX2 Antibody, HRP conjugated ELISA
FITC CSB-PA883628LC01HU BEX2 Antibody, FITC conjugated
Biotin CSB-PA883628LD01HU BEX2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity.
Gene References into Functions
  1. The study reveals that BEX2 promotes colorectal cancer cell proliferation via the JNK/c-Jun pathway, suggesting BEX2 as a potential candidate target for the treatment of CRC. PMID: 28367093
  2. Bex2 affects the invasion and migration ability of glioma cells by regulating beta-catenin PMID: 25490384
  3. Bex2 overexpression promoted cell migration and invasion in glioma cell lines. PMID: 22907646
  4. Bex2 may be an important player during the development of glioma PMID: 23022184
  5. Both BEX2 and INI1/hSNF5 mainly localized in cell nucleus. PMID: 22698742
  6. BEX2 overexpression was associated with breast cancer. PMID: 21384344
  7. BEX2 has a functional interplay with c-Jun and p65/RelA in breast cancer. PMID: 20482821
  8. These results suggest that the conspicuous expression of the tumor suppressor genes BEX2, IGSF4 and TIMP3 in MLLmu acute myeloid leukemias cell lines is the consequence of altered epigenetic properties of MLL fusion proteins. PMID: 19835597
  9. hBex2 may act as a specific regulator during embryonic development by modulating the transcriptional activity of a novel E-box sequence-binding complex that contains hBex2, LMO2, NSCL2 and LDB1. PMID: 16314316
  10. Correlation between BEX2 expression and mixed lineage leukemia chromosomal aberrations are shown in the cell lines. PMID: 17251904
  11. a NGF/BEX2/NF-kappaB pathway is involved in regulating apoptosis in breast cancer cells and in modulating response to tamoxifen in primary tumors PMID: 17638883
  12. BEX2 is implicated in oligodendroglioma biology. PMID: 19412433

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Subcellular Location
Cytoplasm. Nucleus.
Protein Families
BEX family
Tissue Specificity
Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Widely expressed in breast cancer cell lines.
Database Links

HGNC: 30933

OMIM: 300691

KEGG: hsa:84707

STRING: 9606.ENSP00000442521

UniGene: Hs.398989

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