BIN2 Antibody

Code CSB-PA002701GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
BIN2
Alternative Names
BIN2 antibody; BRAP1Bridging integrator 2 antibody; Breast cancer-associated protein 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human BIN2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.
Gene References into Functions
  1. Bin2 is a membrane-sculpting protein that influences podosome formation, motility and phagocytosis in leucocytes. PMID: 23285027
  2. Bin2 is a BAR domain adapter protein structurally related but functionally distinct from family members Bin1 and amphiphysin. PMID: 10903846
Subcellular Location
Cytoplasm. Cell projection, podosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cell projection, phagocytic cup.
Tissue Specificity
Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues.
Database Links

HGNC: 1053

OMIM: 605936

KEGG: hsa:51411

STRING: 9606.ENSP00000267012

UniGene: Hs.14770

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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