CBX2 Antibody

Code CSB-PA613521LA01HU
Size US$166
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  • Western blot
    All lanes: CBX2 antibody at 6µg/ml
    Lane 1: A431 whole cell lysate
    Lane 2: Mouse heart tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 57, 24 kDa
    Observed band size: 57 kDa

  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA613521LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA613521LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CBX2 Polyclonal antibody
Uniprot No.
Target Names
CBX2
Alternative Names
Cbx 2 antibody; CBX2 antibody; CBX2_HUMAN antibody; CDC A6 antibody; CDCA6 antibody; Cell division cycle associated 6 antibody; Cell division cycle associated6 antibody; chromobox homolog 2 (Pc class homolog, Drosophila) antibody; Chromobox homolog 2 antibody; Chromobox homolog2 antibody; Chromobox protein homolog 2 antibody; hromobox homolog 2 antibody; M33 antibody; M33 polycomb like antibody; MOD 2 antibody; MOD2 antibody; Modifier 3 antibody; Modifier3 antibody; Pc class homolog antibody; Polycomb antibody; SRXY5 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Chromobox protein homolog 2 protein (1-211AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CBX2 Antibody (Product code: CSB-PA613521LA01HU) is Non-conjugated. For CBX2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA613521LB01HU CBX2 Antibody, HRP conjugated ELISA
FITC CSB-PA613521LC01HU CBX2 Antibody, FITC conjugated
Biotin CSB-PA613521LD01HU CBX2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

The recombinant human CBX2 (1-211AA) is used as the immunogen to immunize the rabbit to yield the anti-CBX2 antibody. The CBX2 polyclonal antibody exists as an unconjugated IgG isoform. Its purity is 95%+ using protein G purified. It only reacts with human and mouse CBX2, which is a conserved regulatory factor and a polycomb group (PcG) protein. Studies have shown that CBX2 promotes antiviral innate immunity by enhancing the production of type I interferon. This CBX2 antibody has been validated to recognize CBX2 in ELISA, WB, and IHC analyses.

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Target Background

Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). Plays a role in the lineage differentiation of the germ layers in embryonic development. Involved in sexual development, acting as activator of NR5A1 expression.
Gene References into Functions
  1. study indicates a distinct function of the shorter form of CBX2 and by identifying several of its unique targets, can advance our understanding of DSD pathogenesis and ultimately DSD diagnosis and management. PMID: 29998616
  2. These results suggest that CBX2's phosphorylation is critical for its transcriptional repression of target genes. PMID: 28992316
  3. Data show that basal-like subgroup was enriched for aggressive tumors and somatic mutations in trithorax-group genes and it overexpressed polycomb genes EZH2 and CBX2. PMID: 26431491
  4. up-regulated in metastatic castration-resistant prostate cancer and elevated expression correlates with poor clinical outcome PMID: 26877821
  5. CBX2 role in the sex development cascade is to stimulate the male pathway and concurrently inhibit the female pathway. PMID: 25569159
  6. CBX2 upregulation and amplification significantly correlated with metastatic progression and lower overall survival in many cancer types, particularly those of the breast PMID: 25225902
  7. This study does not support CBX2 gene disruption as a common cause of gonadal gonadal disorders of sex development. PMID: 23219007
  8. Two distinct mechanisms are involved in CBX2-mediated gene silencing. The short CBX2-2 isoform would repress the transcription in a PRC1-independent fashion, whereas gene repression by the long CBX2-1 isoform is mediated by the PRC1 protein complex. PMID: 22419124
  9. CDYL functions as a molecular bridge between PRC2 and the repressive chromatin mark H3K27me3, forming a positive feedback loop to facilitate the establishment and propagation of H3K27me3 modifications along the chromatin PMID: 22009739
  10. hPc2 serves as a SUMO E3 ligase for cystathionine beta-synthase, increasing the efficiency of sumoylation. PMID: 19107218

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Involvement in disease
46,XY sex reversal 5 (SRXY5)
Subcellular Location
Nucleus. Chromosome.
Database Links

HGNC: 1552

OMIM: 602770

KEGG: hsa:84733

STRING: 9606.ENSP00000308750

UniGene: Hs.368410

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