CNTROB Antibody

1. cytoplasmic centrobin has roles in noncentrosomal microtubule formation in specific cell types and during the cell cycle PMID: 26083938
2. it is proposed that Centrobin might regulate microtubule nucleation and organization by controlling the amount of pericentriolar matrix PMID: 23442802
3. NEK2 phosphorylation antagonizes the microtubule stabilizing activity of centrobin. PMID: 23291182
4. Our results indicate that genetic polymorphisms of centrobin and Nek2 are related to breast cancer susceptibility in Chinese Han women. PMID: 23001753
5. Centrobin facilitates the elongation and stability of centrioles via its interaction with tubulins. PMID: 21576394
6. Data propose that centrobin functions as a microtubule stabilizing factor and PLK1 enhances centrobin activity for proper spindle formation during mitosis. PMID: 20511645
7. a requirement of Centrobin in maintaining centrosome integrity, which in turn promotes anchoring of mitotic spindle to the centrosomes. PMID: 20190801
8. Inhibition of p38 activity or downregulation of p38 expression could overcome the cell-cycle arrest caused by centrobin depletion. PMID: 20085806
9. Centrobin is a centriole-associated protein that asymmetrically localizes to the daughter centriole. PMID: 16275750
10. Results report that NIP2, previously identified as centrobin, is a novel substrate of Nek2, and that NIP2 has a role in stabilizing the microtubule structure. PMID: 17535851

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HGNC: 29616

OMIM: 611425

KEGG: hsa:116840

STRING: 9606.ENSP00000369614

UniGene: Hs.348012