CNTROB Antibody

Code CSB-PA001554
Size US$100
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  • Western Blot analysis of HuvEc cells using Centrobin Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
CNTROB
Alternative Names
9830165K03Rik antibody; Centrobin antibody; centrobin; centrosomal BRCA2 interacting protein antibody; Centrosomal BRCA2 interacting protein antibody; Centrosomal BRCA2-interacting protein antibody; CNTRB_HUMAN antibody; Cntrob antibody; LIP8 antibody; LYST interacting protein 8 antibody; LYST-interacting protein 8 antibody; LYST-interacting protein LIP8 antibody; PP1221 antibody; RGD1307488 antibody; RP23 26L6.9 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human Centrobin.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.
Gene References into Functions
  1. cytoplasmic centrobin has roles in noncentrosomal microtubule formation in specific cell types and during the cell cycle PMID: 26083938
  2. it is proposed that Centrobin might regulate microtubule nucleation and organization by controlling the amount of pericentriolar matrix PMID: 23442802
  3. NEK2 phosphorylation antagonizes the microtubule stabilizing activity of centrobin. PMID: 23291182
  4. Our results indicate that genetic polymorphisms of centrobin and Nek2 are related to breast cancer susceptibility in Chinese Han women. PMID: 23001753
  5. Centrobin facilitates the elongation and stability of centrioles via its interaction with tubulins. PMID: 21576394
  6. Data propose that centrobin functions as a microtubule stabilizing factor and PLK1 enhances centrobin activity for proper spindle formation during mitosis. PMID: 20511645
  7. a requirement of Centrobin in maintaining centrosome integrity, which in turn promotes anchoring of mitotic spindle to the centrosomes. PMID: 20190801
  8. Inhibition of p38 activity or downregulation of p38 expression could overcome the cell-cycle arrest caused by centrobin depletion. PMID: 20085806
  9. Centrobin is a centriole-associated protein that asymmetrically localizes to the daughter centriole. PMID: 16275750
  10. Results report that NIP2, previously identified as centrobin, is a novel substrate of Nek2, and that NIP2 has a role in stabilizing the microtubule structure. PMID: 17535851

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Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Centriole-associated, asymmetrically localizes to the daughter centriole.
Tissue Specificity
Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
Database Links

HGNC: 29616

OMIM: 611425

KEGG: hsa:116840

STRING: 9606.ENSP00000369614

UniGene: Hs.348012

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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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