COPS3 Antibody

Datasheet

Code	CSB-PA892483ESR1HU
Size	US$166
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Image	Western blot All lanes: COPS3 antibody at 3.41µg/ml Lane 1: MCF-7 whole cell lysate Lane 2: Hela whole cell lysate Lane 3: 293T whole cell lysate Lane 4: HT29 whole cell lysate Lane 5: Mouse heart tissue Lane 6: Mouse brain tissue Lane 7: Mouse ovarian tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 48, 46 kDa Observed band size: 48 kDa Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA892483ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA892483ESR1HU at dilution of 1:100 Immunoprecipitating COPS3 in Hela whole cell lysate Lane 1: Rabbit control IgG instead of (1µg) instead of CSB-PA892483ESR1HU in Hela whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000) Lane 2: CSB-PA892483ESR1HU (4µg) + Hela whole cell lysate (500µg) Lane 3: Hela whole cell lysate (20µg)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) COPS3 Polyclonal antibody

Uniprot No.

Q9UNS2

Target Names

COPS3

Alternative Names

Constitutive photomorphogenic homolog subunit 3 antibody; COP 9 (constitutive photomorphogenic) subunit 3 antibody; COP 9 complex homolog subunit 3 antibody; COP 9 complex S3 antibody; COP 9 complex subunit 3 antibody; COP 9 constitutive photomorphogenic homolog subunit 3 antibody; COP 9 homolog antibody; COP 9 signalosome complex subunit 3 antibody; COP 9 signalosome subunit 3 antibody; COP 9 subunit 3 antibody; COP9 (constitutive photomorphogenic) subunit 3 antibody; COP9 complex homolog subunit 3 antibody; COP9 complex S3 antibody; COP9 complex subunit 3 antibody; COP9 constitutive photomorphogenic homolog subunit 3 antibody; COP9 homolog antibody; COP9 signalosome complex subunit 3 antibody; COP9 signalosome subunit 3 antibody; COP9 subunit 3 antibody; COPS 3 antibody; cops3 antibody; CSN 3 antibody; CSN3 antibody; CSN3_HUMAN antibody; JAB 1 containing signalosome subunit 3 antibody; JAB1 containing signalosome subunit 3 antibody; JAB1-containing signalosome subunit 3 antibody; SGN 3 antibody; SGN3 antibody; Signalosome subunit 3 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human COP9 signalosome complex subunit 3 protein (194-423AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC, IP

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200
IP	1:200-1:2000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunoprecipitation (IP) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene References into Functions

Here the authors identify a potential mechanism by which desmosomes assist the de-neddylating COP9 signalosome (CSN) in attenuating EGFR through an association between the Cops3 subunit of the CSN and desmosomal components, Desmoglein1 (Dsg1) and Desmoplakin (Dp), to promote epidermal differentiation. PMID: 28891468
this study demonstrates Csn3 as an oncogene that regulates the tumorigenesis process in hepatocellular carcinoma (HCC) cells. PMID: 22237956
of the COPS3 gene might have important roles in metastasis of osteosarcoma cells. PMID: 21436869

Subcellular Location

Cytoplasm. Nucleus.

Protein Families

CSN3 family

Tissue Specificity

Widely expressed. Expressed at high level in heart and skeletal muscle.

Database Links

HGNC: 2239

OMIM: 604665

KEGG: hsa:8533

STRING: 9606.ENSP00000268717

UniGene: Hs.6076

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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