CORO1B Antibody

Datasheet

Code	CSB-PA880087LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA880087LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA880087LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA880087LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CORO1B Polyclonal antibody

Uniprot No.

Q9BR76

Target Names

CORO1B

Alternative Names

COR1B_HUMAN antibody; CORO 1B antibody; CORO1B antibody; Coronin 1B antibody; Coronin 2 antibody; Coronin actin binding protein 1B antibody; Coronin-1B antibody; Coronin-2 antibody; Coronin1B antibody; Coronin2 antibody; DKFZP762I166 antibody; OTTHUMP00000236823 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Coronin-1B protein (252-453AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CORO1B Antibody (Product code: CSB-PA880087LA01HU) is Non-conjugated. For CORO1B Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA880087LB01HU	CORO1B Antibody, HRP conjugated	ELISA
FITC	CSB-PA880087LC01HU	CORO1B Antibody, FITC conjugated
Biotin	CSB-PA880087LD01HU	CORO1B Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction.

Gene References into Functions

VEGF-activated p38alpha phosphorylates coronin 1B at Ser2 and activates the Arp2/3 complex by liberating it from coronin 1B. PMID: 27592029
Coronin 1B constitutively binds to TGF beta receptor I in vascular smooth muscle cells. PMID: 28625921
The loss of junctional NMIIA, upon Coronin 1B knockdown, perturbed RhoA signaling. PMID: 27650961
When cells undergo apoptosis in an epithelial monolayer, coronin 1B is recruited to the junctional cortex at apoptotic/neighbor cell interface in an E-cadherin-dependent fashion to support actin architectural reorganization, contractility, and extrusion. PMID: 27046832
Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis. PMID: 23667561
analysis of the mechanism for negatively regulating Rho-kinase (ROCK) signaling through Coronin1B protein in neuregulin 1 (NRG-1)-induced tumor cell motility PMID: 22563075
Coronin 1B regulates leading edge dynamics and controls cell motility and interactions with the actin-related protein (Arp)2/3 complex PMID: 16027158
Study concludes that Coronin 1B's coordination of filament formation by Arp2/3 complex and filament turnover by Cofilin is required for effective lamellipodial protrusion and cell migration. PMID: 17350576
In rabbits, cholinergic stimulation increases the phosphorylation of coronin 1B in gastric mucosal cells PMID: 9915840

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Subcellular Location

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber.

Protein Families

WD repeat coronin family

Database Links

HGNC: 2253

OMIM: 609849

KEGG: hsa:57175

STRING: 9606.ENSP00000340211

UniGene: Hs.6191

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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