CPM Antibody

1. Low CPM expression is associated with colorectal cancer. PMID: 28186967
2. CPM binding to extracellular loop 2 of the B1R results in positive allosteric modulation of B1R signaling, and disruption of this interaction could provide a novel therapeutic approach to reduce pathological B1R signaling. PMID: 24108126
3. Carboxypeptidase M expression is lost in human renal cell carcinoma tumor cells, whereas it is abundant in tumor-associated foam cells and neovasculature. PMID: 23172796
4. novel marker and cellular player in lipid uptake and/or metabolism of activated macrophages by promoting foam cell formation PMID: 22157720
5. CPM and B1Rs on cell membranes form a critical complex that potentiates B1R signaling. PMID: 21454694
6. CPM amplification could be used as an alternative diagnostic tool for the diagnosis of well-differentiated liposarcoma/atypical lipomatous tumors. PMID: 19820690
7. Results report the crystallization of human carboxypeptidase M and its 3.0 angstrom crystal structure. PMID: 15066430
8. Carboxypeptidase M and kinin B1 receptors interact to facilitate efficient b1 signaling from B2 agonists PMID: 18187413
9. Cleavage of the C-terminal lysine residue of SDF-1alpha by CPM leads to attenuated chemotactic responses. PMID: 18292211
10. Multiple transcription start sites in two regions ~30 kb apart are flanked by two unique functional promoters. Five major types of transcripts resulting from multiple transcription start sites and alternate splicing in the 5-prime region were identified. PMID: 11891060
11. CPM is membrane-bound via attachment of glycosylphosphatidylinositol at Ser406. Glu264 is a critical catalytic residue, whereas Glu260 affects stability and substrate kinetics. PMID: 12457462

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HGNC: 2311

OMIM: 114860

KEGG: hsa:1368

STRING: 9606.ENSP00000339157

UniGene: Hs.654387