DAZAP1 Antibody

Code CSB-PA822205LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: Jurkat whole cell lysate
    All lanes: DAZAP1 antibody at 2.8µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 44, 41 kDa
    Observed band size: 44, 70 kDa

  • Immunofluorescent analysis of Hela cells using CSB-PA822205LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DAZAP1 Polyclonal antibody
Uniprot No.
Target Names
DAZAP1
Alternative Names
DAZ associated protein 1 antibody; DAZ-associated protein 1 antibody; Dazap1 antibody; DAZP1_HUMAN antibody; Deleted in azoospermia associated protein 1 antibody; Deleted in azoospermia-associated protein 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human DAZ-associated protein 1 protein (1-300AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The DAZAP1 Antibody (Product code: CSB-PA822205LA01HU) is Non-conjugated. For DAZAP1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA822205LB01HU DAZAP1 Antibody, HRP conjugated ELISA
FITC CSB-PA822205LC01HU DAZAP1 Antibody, FITC conjugated
Biotin CSB-PA822205LD01HU DAZAP1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IF
Recommended Dilution
Application Recommended Dilution
WB 1:2000-1:10000
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
RNA-binding protein, which may be required during spermatogenesis.
Gene References into Functions
  1. Data indicate that DAZAP1 exerts a suppressive effect on cox6c pre-mRNA splicing and reduced DAZAP1 expression increases the COX6C protein level, leading to cell growth retardation. PMID: 29505834
  2. The splicing activator DAZAP1 integrates splicing control into MEK/Erk-regulated cell proliferation and migration. PMID: 24452013
  3. this study reports the mapping of a 42-amino acid segment (N42) at the N-terminus of DAZAP1 that is both necessary and sufficient for its transcription-dependent nuclear localization. PMID: 23111326
  4. Data show that hnRNPA1/A2, HuR and DAZAP1 splicing factors and DHX36 RNA helicase bind to the ISE, with hnRNPA1 acting negatively and DAZAP1 positively on splicing selection PMID: 21858080
  5. DAZAP1 can regulate mRNA translation. PMID: 21576381
  6. data suggest that MEF2D/DAZAP1 and/or DAZAP1/MEF2D contribute to leukemogenesis by altering signaling pathways normally regulated by wild-type MEF2D and DAZAP1 PMID: 15744350
  7. This study shows expression patterns of DAZAP1 in human corpus luteum cells and demonstrates the in vivo interaction of DAZ-like protein (DAZL) with DAZAP1. PMID: 16209998
  8. DAZ cannot bind simultaneously to DAZAP1 and poly(A)-binding protein (PABP), and suggest that the phosphorylation-induced dissociation of DAZ and DAZAP1 may allow the former to stimulate translation by interacting with PABP. PMID: 16848763
  9. The binding of the splicing factors hnRNPA1/A2 and DAZAP1 is the primary determinant of T6 BRCA1 exon 18 exclusion. PMID: 18391021
  10. The results suggest that DAZAP1 is a component of complexes that are crucial for the degradation and silencing of mRNA. PMID: 19285026

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Subcellular Location
Cytoplasm. Nucleus.
Tissue Specificity
Mainly expressed in testis. Expressed to a lower level in thymus. Weakly or not expressed in heart, liver, brain, placenta, lung, skeletal muscle, kidney and pancreas.
Database Links

HGNC: 2683

OMIM: 607430

KEGG: hsa:26528

STRING: 9606.ENSP00000233078

UniGene: Hs.222510

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