DAZAP1

DAZAP1, azoospermia deficiency-associated protein 1, is an RNA-binding protein encoded by the human genome and located in the AZFc region of the Y chromosome. It plays a crucial role in various biological processes, particularly in the male reproductive system, where it is essential for spermatogenesis. By modulating the alternative splicing of numerous genes, DAZAP1 influences critical cellular activities such as proliferation, differentiation, and apoptosis. Furthermore, it has been implicated in cancer progression and metastasis, with its overexpression shown to inhibit the division and migration of cancer cells, highlighting its potential as a therapeutic target. The significance of DAZAP1 extends beyond reproductive biology, as it is involved in various diseases, making it a focal point for ongoing research in both biological and medical fields.