DCUN1D5 Antibody

Code CSB-PA006575GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
DCUN1D5
Alternative Names
DCUN1D5DCN1-like protein 5 antibody; DCUN1 domain-containing protein 5 antibody; Defective in cullin neddylation protein 1-like protein 5 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human DCUN1D5
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth.
Gene References into Functions
  1. evidence that DCNL5 may be involved in innate immunity, as it is a direct substrate of the kinase IKKalpha during immune signalling. PMID: 29958295
  2. SCCRO5 has oncogenic potential that requires its function as a component of the neddylation E3. Neddylation activity and nuclear localization of SCCRO5 are important for its in vivo function. PMID: 24192928
  3. Overexpression of DCUN1D5 is associated with laryngeal squamous cell carcinoma. PMID: 23098533
Subcellular Location
Nucleus. Cytoplasm, cytoskeleton, spindle.
Tissue Specificity
Weakly expressed in testis, skin and immune tissues (thymus, spleen and lymph nodes).
Database Links

HGNC: 28409

OMIM: 616522

KEGG: hsa:84259

STRING: 9606.ENSP00000260247

UniGene: Hs.503716

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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