Product Details

Uniprot No.

Target Names

FBLIM1

Alternative Names

2410043F08Rik antibody; Cal antibody; CSX associated LIM antibody; DKFZp434G171 antibody; FBLI1_HUMAN antibody; FBLIM 1 antibody; Fblim1 antibody; FBLP 1 antibody; FBLP-1 antibody; FBLP1 antibody; Filamin binding LIM protein 1 antibody; Filamin-binding LIM protein 1 antibody; Gt10 antibody; MGC105665 antibody; MIG2 interacting protein; antibody; MIG2-interacting protein antibody; Migfilin antibody; Mitogen inducible 2 interacting protein antibody; Mitogen-inducible 2-interacting protein antibody; OTTHUMP00000003118 antibody; OTTHUMP00000003119 antibody; OTTHUMP00000003120 antibody; OTTMUSP00000011062 antibody; OTTMUSP00000011063 antibody; RP11-169K16.5 antibody; RP23-291H3.1 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human FBLIM1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function

Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion.

Gene References into Functions

data implicate FBLIM1 in the pathogenesis of sterile bone inflammation and our findings suggest CRMO is a disorder of chronic inflammation and imbalanced bone remodeling PMID: 28301468
the present study emphasizes for the first time to our knowledge the role of Migfilin in osteoarthritis(OA) and highlights the importance of cell-ECM adhesion proteins in OA pathogenesis. PMID: 23237804
Migfilin expression is reduced in breast cancer. PMID: 23645746
alpha-parvin, beta-parvin and migfilin were expressed in tumor cells in 53%, 2%, 28% and 53% of effusions and 57%, 20%, 83% and 25% of solid lesions, respectively. PMID: 23099104
Migfilin positively modulates the expression and activity of epidermal growth factor receptor, and Migfilin-mediated migration and invasion depend on epidermal growth factor receptor-induced PLC-gamma and STAT3-signaling pathways. PMID: 22843679
Migfilin promoted beta-catenin degradation by reinforcing the association between beta-catenin and GSK-3beta. PMID: 22246236
Migfilin can activate beta1, beta2 and beta3 integrins and promote integrin mediated responses while migfilin depletion impairs the spreading and migration of endothelial cells PMID: 22043318
The association between filamin B and FBLP-1 may play a hitherto unknown role in cytoskeletal function, cell adhesion, and cell motility. PMID: 12496242
A review of migfilin's role as a key regulator both at cell adhesion sites and nuclei. It's possible role in the pathogenesis of several human diseases is also discussed. PMID: 15701922
Migfilin has a role in interacting with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration PMID: 16531412
Results suggest a role for cytoplasmic migfilin in the progression of leiomyosarcomas (LMS) and identify cytoplasmic migfilin as a potentially important biological marker for human LMS progression. PMID: 17711449
Loss-of-function mutations in KIND1 result in marked variability in kindlin-1 immunolabeling in Kindler syndrome skin, which is mirrored by similar changes in kindlin-2 and migfilin immunoreactivity. PMID: 18528435
analysis of the migfilin-filamin interaction and competition with integrin beta 7 tails PMID: 18829455
Migfilin thus acts as a molecular switch to disconnect filamin from integrin for regulating integrin activation and dynamics of extracellular matrix-actin linkage. PMID: 19074766
Migfilin interacts with Src and contributes to cell-matrix adhesion-mediated survival signaling PMID: 19833732

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Subcellular Location

Cell junction, focal adhesion. Cytoplasm, cytoskeleton, stress fiber.

Tissue Specificity

Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets.

Database Links

HGNC: 24686

OMIM: 607747

KEGG: hsa:54751

STRING: 9606.ENSP00000416387

UniGene: Hs.530101