GABRD Antibody

Code CSB-PA009149GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
GABRD
Alternative Names
GABA(A) receptor subunit delta antibody; Gabrd antibody; Gamma aminobutyric acid GABA A receptor delta antibody; Gamma aminobutyric acid receptor delta subunit precursor GABA A receptor antibody; Gamma-aminobutyric acid receptor subunit delta antibody; GBRD_HUMAN antibody; MGC45284 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human GABRD
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene References into Functions
  1. This study found that increased methylation of the promoter of the delta subunit GABAA receptor was associated with reduced mRNA and protein levels in the cerebellum of alcohol use disorder subjects. PMID: 29020412
  2. Genome-wide association studies identify GABRD mutation releated to juvenile myoclonic epilepsy PMID: 23756480
  3. In recombinant human cDNA experiments in HEK293 cells, delta subunit coexpression leads to receptors activated by nanomolar THIP concentrations. PMID: 21795619
  4. These findings point to the GABRD gene as a susceptibility gene for COMD. PMID: 20561060
Involvement in disease
Generalized epilepsy with febrile seizures plus 5 (GEFS+5); Epilepsy, idiopathic generalized 10 (EIG10); Juvenile myoclonic epilepsy 7 (EJM7)
Subcellular Location
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein Families
Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRD sub-subfamily
Database Links

HGNC: 4084

OMIM: 137163

KEGG: hsa:2563

STRING: 9606.ENSP00000367848

UniGene: Hs.113882

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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