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As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents. Hydrolyzes GTP, but in contrast to other family members, does not produce GMP.
Gene References into Functions
GBP5 and KLF2 may be useful as a diagnostic tool for active tuberculosis, also the two-gene set may serve as surrogate biomarkers for monitoring tuberculosis therapy. PMID: 28941629
these results reveal that GBP5 inhibited influenza virus replication through the activation of IFN signaling and proinflammatory factors PMID: 28376501
Previously reported tetrameric and dimeric species of hGBP-1 and hGBP-5 were unmasked as dimers and monomers, respectively, with their shapes depending on both the bound nucleotide and the ionic strength of the solution. PMID: 28580591
Antiviral activity requires Golgi localization of GBP5, but not its GTPase activity. PMID: 26996307
GZMA, GBP5 and CD64 genes show promise as a rapid diagnostic markers separating tuberculosis from other pulmonary diseases. PMID: 26025597
The in vivo localization of GBP-5 at the Golgi apparatus is regulated by isoprenylation and dimerization. PMID: 21151871
analysis of guanylate binding protein 5 and a tumor-specific truncated splice variant PMID: 20180847
Eight of nine melanoma cell lines expressed GBP-5a/b and four of nine additionally low levels of GBP-5ta. PMID: 15175044
3 genes were upregulated in patients with chronic EBV infection: guanylate binding protein 1, tumor necrosis factor-induced protein 6, and guanylate binding protein 5; they may be associated with the inflammatory reaction or with cell proliferation. PMID: 18260761
GBP5 is constitutively localized in the Golgi apparatus of endothelial cells. PMID: 17266443