GRAP2 Antibody

1. These data are consistent with a model in which bivalent recruitment of a GADS/SLP-76 complex is required for costimulation by CD6. PMID: 28289074
2. Following phosphorylation of the tyrosine, the proteins growth factor receptor-bound protein 2 (Grb2), Grb2-related adaptor downstream of Shc (Gads), and p85 subunit of phosphoinositide 3-kinase may bind to pYMNM (where pY is phosphotyrosine) via their Src homology 2 (SH2) domains, leading to downstream signaling to distinct immune pathways. These three adaptor proteins bind to the same site on CD28 with variable affinity PMID: 27927989
3. GADS deficient T cells displayed similar levels of T cell receptor -induced SLP-76 and PLC-gamma1 phosphorylation but exhibited substantial decrease in TCR-induced IL-2 and IFN-gamma release. PMID: 25636200
4. Gads was dispensable for TCR-induced phosphorylation of SLP-76, but was a dose-dependent amplifier of TCR-induced CD69 expression. PMID: 25452106
5. GADS mediates lymphoid disease downstream of BCR-ABL through the recruitment of specific signaling intermediates. PMID: 23399893
6. Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL PMID: 21179510
7. The results show that Bcr-Abl regulates the actin cytoskeleton and non-apoptotic membrane blebbing via a GADS/Slp-76/Nck1 adaptor protein pathway. PMID: 20079431
8. Upstream open reading frames regulate translation of this protein's mRNA in megakaryocytes. PMID: 12487779
9. Exogenous expression of GrpL in a GrpL-negative B cell line leads to enhanced antigen receptor-induced extracellular signal-related kinase and p38 mitogen-activated protein kinase phosphorylation. PMID: 12496419
10. AML-1 plays a role in driving Mona protein expression in T and myelomonocytic cells. PMID: 12554803
11. Plays a tissue-specific role as an inhibitor of RET receptor tyrosine kinase mitogenic signaling PMID: 12917638
12. Gads plays a dominant role in CD28-mediated IL-2 promoter activation. PMID: 16818765
13. The integrity of T-cell receptor signaling in vivo is sustained both by strong selection of SLP-76 for the Gads C-SH3 domain and by a capacity to buffer intrinsic crossreactivity. PMID: 17235283
14. Consistent Grap-2 expression suggests a specific role for this adaptor in human medullary thyroid carcinoma, while qualitative alterations do not appear to influence RET signaling PMID: 19027225

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HGNC: 4563

OMIM: 604518

KEGG: hsa:9402

STRING: 9606.ENSP00000339186

UniGene: Hs.517499