GSR Antibody

1. It has been shown that acute aerobic exercise activates Nrf2 in young men, irrespective of training intensity, but that high-intensity exercise demonstrated a greater effect on increasing glutathione reductase activity which could indicate improved redox potential. PMID: 28693341
2. GSR expression was higher in TMZ-resistant cells than in sensitive cells. GSR silencing in drug-resistant cells improved the sensitivity of cells to TMZ or cisplatin. Over-expression resulted in resistance. GSR partially prevented the oxidative stress caused by L-buthionine -sulfoximine. The action of GSR in drug resistance is associated with the modulation of redox homeostasis. High GSR correlated with lower survival. PMID: 29105080
3. Plasma glutathione reductase (GR) activity was correlated with erythrocyte GR activity and the erythrocyte reduced glutathione/glutathione disulfide ratio. A decrease in plasma GR activity was associated with an increase in mortality in septic shock. PMID: 26316444
4. Glutathione reductase reduces mitochondrial protein mitoNEET [2Fe-2S] clusters. PMID: 25645953
5. The recurrence of benign tumors of mammary gland occurred predominantly in women-carriers of mutant alleles with polymorphism rs8190924 of gene GSR and AA rs3763511of gene DKK4. PMID: 26419038
6. GSR was the most significant single SNP association with systemic lupus erythematosus in African Americans. PMID: 23637325
7. The results demonstrate for the first time that glutathione reductase gene polymorphisms are significantly associated with bone mineral density. PMID: 22089180
8. Up-regulation of CAT and GR activity resulted in an increase in total antioxidant activity in A549 after exposure to B(a)P. PMID: 21417634
9. Human eye lenses were dissected into discrete regions that were formed at different stages of life and assayed for activity of lactate dehydrogenase (LDH) and a particularly stable enzyme, glutathione reductase (GR). PMID: 20586645
10. novel glutathione reductase alternative splice variants PMID: 20628807
11. GR deficiency and drug-induced GR inhibition may protect from malaria by inducing enhanced ring stage phagocytosis rather than by impairing parasite growth directly [case study] PMID: 19806191
12. Malignant lung tumors (squamous cell carcinoma and adenocarcinoma) had increased activity of this enzyme. PMID: 12447480
13. activities of catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx) and superoxide dismutase (SOD) were decreased during intense physical exercise PMID: 12516882
14. An oxidative stress marker after kidney transplantation PMID: 12826156
15. Patients with chronic alcoholism (PCA) of stage II have increased glutathione reductase (GR) activity in neutrophils, lymphocytes and monocytes compared with that in the cells of healthy donors PMID: 12838767
16. GR activity in COPD and chest osteomyelitis decreased by 40% and more, lung tumors--by 32-36%. PMID: 12838770
17. serum concentrations in patients with chronic lymphocytic leukemia PMID: 14637279
18. Decreased activities of erythrocyte glutathione reductase is associated with cerebral palsy PMID: 15978628
19. Data show that both glutathione and glutathione reductase are inducible by D3T, and that upregulation of GSH biosynthesis underlies D3T-mediated cytoprotection against ROS/RNS-elicited injury to human vascular smooth muscle cells. PMID: 17206382
20. Inhibitory effects of several antibiotics on purified human erythrocyte glutathione reductase has been investigated. PMID: 18341267
21. Data report synchrotron-based cryocrystallographic studies of natural substrate complexes of the flavoenzyme human glutathione reductase at nominal resolutions between 1.1 and 0.95 A that reveal new aspects of its mechanism. PMID: 18638483
22. higher glutathione reductase and total antioxidant capacity were found in end-stage renal disease patients than in controls PMID: 19377255

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HGNC: 4623

OMIM: 138300

KEGG: hsa:2936

STRING: 9606.ENSP00000221130

UniGene: Hs.271510